Reports in recent years have emphasized that it is best to cooperate with drugs that have the effect of increasing white blood cells while treating according to syndrome differentiation. Studies have confirmed that the drugs that have obvious curative effects on leukopenia and thrombocytopenia caused by radiotherapy and chemotherapy are: Radix Astragali, Radix Angelicae Sinensis, Radix Pseudostellariae, Atractylodis Macrocephalae, Colla Corii Asini, Carapax et Plastrum Testudinis, Squama Manis, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Caulis Paederiae, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Psoraleae, Colla Cornu Cervi, Peanut Skin, Mole Powder, and Fructus Jujubae .. The selection of these drugs must be guided by the principle of syndrome
First, dialectical medication
1. Qi deficiency type
Leukopenia in the blood, accompanied by pallor, chest tightness, shortness of breath, palpitation, weakness of limbs, aversion to food, thirst, loose stool, sometimes edema of limbs, spontaneous sweating, thready pulse, fat tongue or teeth marks, thin white or greasy fur. Treatment principle: benefiting qi and regulating stomach, warming spleen and kidney. Yiqi Decoction: Radix Codonopsis, Atractylodis Rhizoma, Radix Paeoniae Alba, Poria, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Psoraleae, Radix Aucklandiae, Colla Cornu Cervi, Arillus Longan, Fructus Lycii, Pericarpium Citri Tangerinae, Radix Astragali 12g.
2. Qi deficiency and blood deficiency type
Leukopenia in the blood, accompanied by dizziness, mental fatigue, sallow or gray complexion, loss of appetite, frequent urination, false stool, pale tongue, thin fur and soft pulse. Treatment should benefit qi and nourish blood. The prescription is Danggui Buxue Decoction and Buzhong Yiqi Decoction: Angelica sinensis, Ginseng and Atractylodes macrocephala each 10g, Glycyrrhiza uralensis, Pericarpium Citri Tangerinae, Cimicifuga Rhizoma and Bupleuri Radix each 6g, and Astragalus membranaceus 15g.
3. Yin deficiency and internal heat type
The leukopenia in the blood is accompanied by dizziness, insomnia, vexation, thirst, cold drinks, gingival bleeding, nosebleed, red urine, constipation, fever, night sweats, loss of appetite, rapid pulse, red tongue, thin fur or shedding. Treatment should be nourishing yin and promoting fluid production, clearing away heat and calming the nerves. Prescription of Ziyin decoction: 9 grams each of Radix Rehmanniae, Radix Paeoniae Alba, Radix Asparagi, Radix Ophiopogonis, Radix Scrophulariae, Radix Angelicae Sinensis, Cortex Moutan, Fructus Lycii, Radix Adenophorae, Cortex Lycii and Radix Codonopsis, 5 grams each of Trichosanthis Radix, Eclipta prostrata and Schisandra chinensis.
4. Liver and kidney deficiency type
Leukopenia in the blood, accompanied by dizziness, tinnitus, backache, restlessness, insomnia at night, dry mouth, insufficient body fluid and thready pulse. Treatment: nourishing liver and kidney, benefiting qi and nourishing blood. Danggui Buxue Decoction and Liuwei Dihuang Pill: Radix Rehmanniae Preparata 10g, Rhizoma Dioscoreae 10g, Fructus Corni 10g, Poria 10g, Rhizoma Alismatis 10g, Cortex Moutan 10g, and Radix Angelicae Sinensis/kloc-.
5. Spleen and kidney yang deficiency type
White blood cells in the blood drop, accompanied by soreness of the waist and knees, cold limbs, pallor, fatigue, loose stool anorexia, pale tongue or tooth marks, and weak pulse. Treatment should be tonifying kidney and spleen, nourishing yin and nourishing blood. Drugs such as: 5g of Radix Aconiti Lateralis Preparata, 9g of Cornu Cervi Pantotrichum, 9g of Radix Morindae Officinalis, 9g of Herba Epimedii, 3g of Fructus Psoraleae 12g, 3g of Cortex Cinnamomi, 3g of Radix Astragali 12g of Radix Angelicae Sinensis 12g of Caulis Spatholobi 12g of Radix Morindae Officinalis12g of Radix Rubiae.
Second, empirical prescription.
In the treatment of leukopenia caused by radiotherapy and chemotherapy, many effective experiences have been summarized clinically. The following experience can be used for reference.
1. Sheng Baijian
Ginseng 15g, Radix Rehmanniae Preparata 50g, Radix Astragali 50g, Radix Codonopsis 20g, Radix Angelicae Sinensis 20g, Caulis Spatholobi 20g, Folium Pyrrosiae 20g, Radix Salviae Miltiorrhizae 15g, Poria cocos 15g, and Polygonum Multiflori Radix 25g. Decoct the above liquid medicines to obtain juice, and then brew them into placenta Hominis powder, tortoise plastron powder and cornu Cervi powder/kloc-respectively. Daily 1 dose, 2 ~ 3 times orally. The treatment of leukopenia caused by postoperative radiotherapy for seminoma can effectively prevent the interruption of treatment due to leukopenia.
2. Bai Sheng pills
Taking 65438 0400g of Astragalus membranaceus, 65438 0200g of Pseudostellaria heterophylla, 65438 0200g of Angelica sinensis and 700g of Alisma orientalis, and making into powder; Another 2000 grams of Salvia Miltiorrhiza, 2000 grams of Spatholobus Spatholobus, 0/200 grams of Pyrrosia/KLOC-and 800 grams of Pericarpium Citri Tangerinae were decocted in water to remove residues and made into paste. Then mix the medicinal powder with the decocted paste, and make into honeyed pills, each pill is 65438 00 g, and take 65438 00 g in the morning and evening respectively. It can effectively prevent leukopenia caused by radioactive source 60 cobalt and has obvious recovery effect on leukopenia.
Step 3: Raise the white drink.
Codonopsis pilosula 15g, Radix Astragali 15g, Radix Angelicae Sinensis 15g, Radix Rehmanniae 15g, Fructus Ligustri Lucidi 15g, Caulis Spatholobi 15g, Rhizoma Smilacis Glabrae 15g, and Atractylodis Rhizoma. Addition and subtraction: Yin deficiency plus Shengdi Turtle Edition; Yang deficiency plus Morinda officinalis and Rhizoma Curculiginis; Blood deficiency plus Semen Ziziphi Spinosae and Caulis Polygoni Multiflori; Cortex Phellodendri and Rhizoma Alismatis are added to damp heat. Usage: daily 1 dose, decocted with water. Check the blood picture in 7 days. According to reports, the total effective rate of this prescription in treating leukopenia caused by chemotherapy is 93%.
4. Compound Longzao Decoction
90g of Herba et Gemma Agrimoniae, 50g of Fructus Jujubae, 50g of Semen Phaseoli, 30g of Polygonatum sibiricum, 30g of Fructus Crataegi, 30g of Caulis Spatholobi, 20g of Radix Angelicae Sinensis, and 0/0g of Radix Glycyrrhizae 1 dose daily. When taking the medicine, add 30g of brown sugar and yellow wine 10ml.
In addition, Shengbaibao (2 capsules each time, 2 ~ 3 times a day) has also been used to prevent and treat leukopenia caused by radiotherapy and chemotherapy. During the period of chemotherapy and radiotherapy with western medicine, ginseng should be taken more, and the dose should be reduced at intervals, 5 ~ 15g per day, cut into small pieces, put into the patient's mouth for many times to swallow its juice, and chew it up and swallow it after softening. According to clinical observation, leukopenia caused by chemotherapy or radiotherapy is increased to varying degrees after taking ginseng. It can not only prevent leukopenia, but also alleviate the symptoms of digestive tract and nervous system caused by toxic and side effects of chemotherapy.
Third, the diet prescription
Diet should be light and nutritious, and avoid being fat, sweet and greasy, so as to prevent wet and sleepy. During the infection period of acute agranulocytosis, warm and nourishing food, such as spicy food, shrimp and crab, should be carefully eaten. Clinically, in the period of chronic leukopenia, we should eat products that invigorate the spleen and kidney, replenish blood, replenish qi and nourish yin, and should not be cold.
Drugs and foods that can be used for dietotherapy include Jujube, Polygonatum, Polygonum cuspidatum, Carapax et Plastrum Testudinis, Colla cornus Cervi, Caulis Spatholobi, Radix Pseudostellariae, Huang Mao, Fructus Amomi, Pericarpium Citri Tangerinae, Fructus Citri Sarcodactylis, Radix Ophiopogonis, Fructus Ligustri Lucidi, shredded cocoon, auricularia auricula, lean meat and cooked beef.
1. Black fungus and red jujube porridge
30 grams of auricularia auricula, 20 grams of red dates, japonica rice and auricularia auricula each, soaked in water and torn into small pieces. Soak jujube in boiling water, then remove the core and cut into pieces, and add fine stains for 20 minutes. Cook auricularia auricula and japonica rice into porridge, then add jujube and red sugar and cook for 20 minutes. Breakfast, dinner or snacks can be eaten.
2.placenta hominis porridge
Half a fresh Placenta Hominis, 250g lean pork, 0/0 slice of ginger and 0/00g glutinous rice. Take placenta fascia and blood vessels, remove blood stasis, wash and cut into pieces with lean pork, shred ginger, cook porridge with japonica rice, add onion, salt and a little seasoning after porridge is cooked. Take it 2-3 times a week for 20 times.
3. Lycium barbarum mutton bone porridge
50g of medlar, 500g of sheep bone, 3 loquat black beans, 50g of jujube 10 and japonica rice. Crush sheep bones, put them into a casserole together with Lycium barbarum, black beans, jujube and japonica rice, add water to cook porridge, and season them. You can take it every other day for a long time 1 time.