If you compare anti-aging to studying, then skincare products containing hyaluronic acid are like tutorials. It's a good idea to learn from the book, but only if you can read it. Although hyaluronic acid can help skin moisturizing, but the hyaluronic acid molecules added to the skin care products can be absorbed into the skin of the few and far between, just like buying a pile of books but can not read into a few words, so the learning curve can not be improved much.

Caffeine-containing skin care products can promote blood circulation in the face, improve facial edema and vascular dark circles. But it's like your parents driving you to and from school, saving you time on the road and preventing you from running off to play on the way out of school. And how efficiently you study afterward is still up to you.

Skin care products containing Vitamin A alcohol help stimulate collagen production and increase skin elasticity, but it's hard to avoid being irritating and needing to build up a tolerance, especially not for sensitive skin. It's like a very strict teacher, holding a whip behind you to urge you to study, although the academic performance will help, but the process is really quite torturous, and really not suitable for some students.

Not that these ingredients are bad, but how to study efficiently? Without a doubt, of course, it's active learning!

Similarly, how to anti-aging effect is good?

That is, of course, by the cell active anti-aging!

How can the cells take the initiative to fight against aging?

This is not to mention the mysterious power of anti-aging Sirtuins protein family !

Sirtuins (SIRT) are a class of deacetylating enzymes that are widely distributed in the cell, and are simply a family of proteins that make up a large family of longevity proteins.

There are seven recognized members of this family: SIRT1-SIRT7, which are widely distributed in cells and have diverse functions. Michishita et al. 2005 found that SIRT1, SIRT6, and SIRT7 are distributed in different parts of the nucleus, with SIRT1 mainly in the nucleolus, SIRT7 in the nucleolus, and SIRT2 in the nucleus. SIRT1 is mainly in the nucleolus, SIRT7 is mainly in the nucleolus, SIRT2 is usually in the cytoplasm, and SIRT3, SIRT4, and SIRT5 are more common in the mitochondria, of which SIRT3 is mainly in the inner membrane of the mitochondria, and SIRT5 is mostly in the lumen of the inner membrane of the mitochondria and in the stroma.

The Sirtuins family of proteins is widely distributed in cells and is involved in the regulation of cell differentiation and apoptosis, metabolism and genome stability. Since Sirtuins are NAD+-dependent histone deacetylases, they regulate the aging process by altering protein activity and stability through lysine deacetylation.

In particular, the activation of the anti-aging triad SIRT1, SIRT3 and SIRT6, which greatly enhance cellular vitality, activate cellular anti-aging potential, and allow cells to actively fight aging and antioxidants, thus realizing more efficient anti-aging.

Here we introduce the anti-aging trio of this family -

Living up to its mission as the big brother of the family, it is the focus of current research in the application of anti-aging field.

SIRT1 can protect cells and prevent cellular aging, it can maintain the normal cell cycle of fibroblasts and maintain sufficient collagen in the dermis. If the fibroblasts in the skin are metabolically disturbed and aged, they cannot produce collagen fibers normally, and the skin will be prone to wrinkles, reduce elasticity, and become loose and sagging.

SIRT3 is a member of a family with great potential, and its main role is to maintain mitochondrial function and provide energy to the cells in a stable manner, which in turn slows down apoptosis and prolongs the life of the cells.

In addition, SIRT3 can activate cellular autophagy, preventing the accumulation of age pigment or lipofuscin in cells, which can lead to melasma, age spots, and manifestations of skin aging.

SIRT6 also protects cells, especially from UV damage to cellular DNA.SIRT6 is involved in repairing DNA damage, stabilizing the genome, preventing cellular senescence, and prolonging cellular life.

Oxidative and stress damage, for example, promotes cellular senescence, which in turn leads to senescence of the overall state of the organism. Therefore, factors like the Sirtuins family of proteins, which have multiple intracellular roles in sensing damage and protecting cells, helping to increase cell survival and ameliorate cellular senescence, can be more targeted to maintain cells at a more viable level, thus helping us to be the youngest littermates in the entire GAI.

So how do you get the Sirtuins to "work"?

And that brings us to activators.

Studies have shown that resveratrol, SRT2104, and NMN are effective in activating Sirtuins, with resveratrol and NMN receiving much attention. (Related article: Hotter Than Meta-Cosmos? Is NMN a Myth or a Joke)

Adding the SIRT1 activator resveratrol before UV irradiation protects the fibroblasts in the skin from elastin fiber degradation and promotes the regeneration of collagen, which prevents the skin from decreasing in elasticity and producing wrinkles. It also prevents H2O2-induced apoptosis and inhibits cellular senescence. In other words, resveratrol not only prevents photoaging, but also has great potential in improving cellular aging. And, in addition to making cells actively anti-aging and antioxidant, it can also induce cell autophagy, regulate normal cell metabolism, and inhibit tyrosinase activity in melanocytes.

Resveratrol is high in grapes, mulberries, blueberries, etc. (it's not anthocyanin, don't get confused). In addition, resveratrol is also added to some skincare products to produce anti-aging effects with other ingredients***, so you can look for skincare products with related ingredients.