The latest data show that Pueraria lobata has alpha receptors and angiotensin II receptors also have a blocking effect, the efficacy is better than the previous types of anti-hypertensive drugs. In particular, it may reverse hypertension-induced myocardial hypertrophy. Puerarin can make the significantly increased plasma endothelin (ET) levels quickly return to normal, so one of the mechanisms of Puerarin treatment of hypertension may lie in the ability to inhibit the excessive release of ET, promote the endothelial restoration of function, which in turn excites the activity of PG12 synthetase, significantly increase EC generation PG inhibition of platelet aggregation, and play a role in improving blood circulation. Large doses of Puerarin can reduce blood glucose, can significantly reduce serum cholesterol.
2, Pueraria Mirifica anti-cancer
Researchers using modern separation methods, extracted from Pueraria Mirifica total flavonoids components for animal testing found that the rate of inhibition of gastric cancer in mice up to the standard of 77.77%, the rate of inhibition of lung cancer in rats up to 55.65%. After the study, it was found that Pueraria lobata flavonoids have obvious effects of increasing the activity of NK cells, SOD and P450. The results of the population intervention test conducted in areas with high incidence of esophageal cancer proved that Pueraria Mirifica total flavonoids did have significant blocking effect on basal cell hyperplasia in patients with cancer.
Effects of Pueraria Mirifica:
Expanding the yang and relieving muscles, transmitting rashes and stopping diarrhea, eliminating vexation and quenching thirst. It can be used to treat typhoid fever, warm fever, headache and strong collar, irritable fever and thirst, diarrhea, dysentery, echium rash, hypertension, angina pectoris, deafness.
Effects of Pueraria Mirifica:
1
Effect on smooth muscle
The soybean glycoside element in Pueraria Mirifica has an anti-acetylcholine effect, and it can significantly contract smooth muscle, which is considered to be the main ingredient of Pueraria Mirifica antispasmodic effect.
2
Effects on coronary circulation
The decoction of Pueraria Mirifica, alcoholic extract, total flavonoids and puerarin all have significant coronary vasodilating effects, which can increase the coronary blood flow and reduce vascular resistance.
3
Effects on myocardial infarction and arrhythmia
The alcoholic extract of Pueraria Mirifica, soybean glycosides and puerarin have obvious effects against the arrhythmia induced by aconitine and barium chloride, and puerarin can also significantly shorten the time of arrhythmia induced by chlorine seems and adrenaline in rabbits, and puerarin can significantly reduce the scope of myocardial infarction, and it is considered to be a kind of β-adrenergic receptor blocker.
4
Effects on cardiac function and myocardial metabolism
Total flavonoids of Pueraria Mirifica and Puerarin can slow down the heart rate, lower the total peripheral resistance of the heart, and reduce the oxygen consumption of the myocardium; and improve the efficiency of myocardial work. Puerarin can also significantly reduce ischemia-induced myocardial lactate production and improve the metabolism of infarcted myocardium.
5
Effects on blood pressure and peripheral vasculature
Total Pueraria Mirifica ketones and Puerarin can make the plasma renin activity and angiotensin significantly reduce the blood pressure down. Puerarin has a significant improvement effect on microcirculation disorders, which is mainly manifested by increasing the amplitude of microvascular movement and improving the local microblood flow; Pueraria lobata total flavonoids have a significant dilatation of cerebral blood vessels, improving cerebral microcirculation and peripheral circulation. Pueraria Mirifica is also reported to improve the blockage of retinal vascular end-units, thus improving visual function.
6
Inhibition of platelet aggregation
Gerberellin can inhibit platelet aggregation induced by adenosine diphosphate (ADP) and the combination of 5-HT (5-hydroxytryptophan) and ADP in both humans and animals; in addition, gerberellin can significantly inhibit the release of 5-HT in platelets induced by thrombin, which is characterized by its antithrombotic effect.
7
Hypoglycemic effect
Gerberellin can antagonize the blood glucose-raising effect of adrenaline, and has certain hypoglycemic ability.
8
Effect on body temperature
The total flavonoids of Pueraria Mirifica have a long-lasting and obvious hypothermic effect on endotoxin-induced temperature elevation, and are commonly used clinically for external fever.
9
Effects on memory
The total flavonoids and alcoholic extracts of Pueraria Mirifica can increase the content of acetylcholine in the cerebral cortex and hippocampus of rats, and reduce the activity of hippocampal acetylcholine transferase, and counteract the memory-acquisition disorders of the rats effected by dongleine, which suggests that Pueraria Mirifica has the capacity to improve the learning and memory to some extent.