Sheep with good constitution have no obvious symptoms after infection. Seriously infected people can be divided into acute and chronic. Acute patients are in critical condition, with elevated body temperature, poor spirit, loss or cessation of appetite, abdominal distension and pain, dyspepsia, anemia and pale eye mucosa. Experimental examination showed that red blood cells, white blood cells and hemoglobin were significantly reduced, and no eggs were found in feces, and they died within a few days.

In chronic cases, adults parasitize the bile duct, and the symptoms are gradually emaciation, anemia, pale mucosa and rough hair. Eyelid, jaw, lower chest edema, loss of appetite, dyspepsia, mild and long-term illness, anatomical liver atrophy and sclerosis, bile duct dilatation and obstruction.

The disease is mainly endemic, especially in summer and autumn. This is because the higher temperature and longer sunshine time in summer and autumn are beneficial to the development of Fasciola hepatica and promote the hatching of miracidium. At this time, there is more rainfall, which leads to a large number of cercariae breeding and attaching to plants to develop cysticercosis, which leads to sheep being infected with the disease.

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