Bone cancer is a kind of malignant tumor with great harm, and it is not easy to be detected in the early stage, most of the bone cancer patients are detected in the middle or late stage, and advanced bone cancer is easy to spread and metastasize, which makes it more difficult to be treated. For advanced bone cancer patients, how long they can live is the most concerned issue. Experts from tumor hospitals said that although the treatment of advanced bone cancer is more difficult, but if the treatment is timely and appropriate, it can still effectively control the condition and prolong the patients' life, and tumor biotherapy is such an advanced technology. When bone cancer develops into advanced stage, there will be spreading of cancer cells, which usually indicates further deterioration of the condition. Therefore, it is very important to carry out timely and effective treatment to curb metastasis of the cancer, control the symptoms and stabilize the condition, and the symptoms of spreading of bone cancer in the advanced stage are as follows: 1) A hard lump can be touched on the surface of bone, which is painful or painless. 2) Skin ulceration can occur in some parts of the body, which is painful or not. 3) The skin may become ulcerated. Some parts of the body will also have symptoms such as skin ulceration. The distal end of the affected limb will produce numbness due to the compression of neurovascularity. 2. Fever, weight loss, fatigue and reduced mobility, sometimes these symptoms of bone cancer spreading may occur in advanced bone cancer, benign bone cancer usually has no pain, so the above situations should be taken seriously and timely consult a doctor. 3. The most typical symptom of bone cancer spreading is bone pain. Bone and joints are painful or swollen, and the pain is aggravated at night, and it is not necessarily related to activities; the pain can be constant dull pain, or pain only when pressure is applied. 4、Spontaneous fracture. Pathologic fractures or deformities occur. There is one or more fractures with no apparent cause. After the fracture is treated, the doctor should be allowed to check in detail whether there is any disease such as osteosarcoma or osteoporosis. Biological therapy prolongs the life of patients with advanced bone cancer and realizes survival with tumor Biological therapy is the application of biotechnology to kill and maim the tumor by regulating and enhancing the immune defense mechanism of tumor patients' body, which not only has obvious killing effect on tumor cells, tumor stem cells and other tumor cells in non-proliferative stage, but also improves the immune force of the body. Thus, it can effectively remove the residual tumor cells in the patient's body and prevent the metastasis and recurrence of the tumor. Biotherapy is the most mature and widely used treatment method at present. Biotherapy effectively combines various therapeutic means to make tumor treatment a continuous integrated treatment, which can improve the effect of tumor treatment as a whole. Because biological therapy not only has obvious killing effect on tumor cells, but also tumor stem cells and other tumor cells in non-proliferative stage, and can improve the immune function of the body. Therefore, in the comprehensive treatment plan for tumors, biotherapy becomes a very key measure to ultimately improve the cure rate and efficiency of tumors.