Loratadine is a second generation antihistamine, which is often used to treat allergic symptoms. Can be used for treating allergic rhinitis, acute and chronic urticaria, allergic conjunctivitis, pollinosis and other allergic dermatoses.

Antihistamines have high selectivity to peripheral nerve H 1 receptor, strong action and long action time. It is a long-acting tricyclic antihistamine, which competitively inhibits histamine H 1 receptor and inhibits allergic symptoms caused by histamine. There is no obvious anticholinergic and central inhibitory effect. Can be used for relieving symptoms related to allergic rhinitis, and relieving symptoms of chronic urticaria and other allergic dermatoses.

Piperidine antihistamine, a derivative of azatadine, has the function of selectively antagonizing peripheral histamine H 1 receptor. Its antihistamine effect is rapid, strong and lasting. Its effect is stronger than that of astemizole and terfenadine. This product has no sedative effect and no anticholinergic effect. It has no enhancement effect on ethanol. It is absorbed quickly and well after oral administration.

The peak time tmax of blood drug concentration was 65438 0.5 hours. The binding rate with plasma protein was 98%. Most of them are metabolized in the liver, and the metabolite desloratadine still has antihistamine activity. This product and its metabolites are excreted in urine and feces, and the time of t 1/2 is about 20 hours. This product and its metabolites are not easy to pass through the blood-brain barrier, but can appear in milk.