Wild puffer fish cooked at high temperature cannot be safely eaten. In fact, tetrodotoxin is extremely stable in nature, and it can't be destroyed by high-temperature cooking, pickling and sun exposure. According to reports, generally after eating puffer fish poisoning for 20 minutes, there will be early symptoms such as slight numbness in the mouth, lips, tongue tip and fingers, followed by vomiting, difficulty in walking, difficulty in speech, inability to exercise, and then rapid drop in blood pressure, difficulty breathing until consciousness disappears, breathing and heartbeat stop and die.