Hives is a common allergic skin disease, in contact with allergens, in the body of unspecified parts of the emergence of a piece of red patches of varying shapes and sizes, these plaques produce parts of the itchy situation, if you do not stop contact with the allergens and to treat the itchy situation will worsen the appearance of the rash. Antimicrobials are often used when there is an infection, and food allergies can be avoided. Chronic foci of infection are often the cause of chronic urticaria, but in some patients with urticaria the cause is difficult to determine or cannot be found. Treatment in addition to antihistamines, can use rifampicin, aminophylline, amlodipine, 6-aminocaproic acid, vitamin K, vitamin E, vitamin B12, histaminoglobulin, transfer factor, procaine, etc.