Taenia solium is a parasitic disease of human and livestock that seriously harms human health and animal husbandry production. The disease is worldwide, mainly prevalent in Central Africa, South Africa, Latin America, East Asia and South Asia. In China, it is mainly prevalent in 365,438+0 provinces (cities, autonomous regions) such as Heilongjiang, Jilin, Yunnan, Henan, Hebei, Shandong and Guangxi. According to the national survey of human parasite distribution. The infection rate of Taenia solium in China is 0. 1 12%, and it is as high as 0.66% ~ 6.00% in some areas. The number of infected people was 6.5438+0.26 million, the infection rate of cysticercosis was 0.654.38+0.4% ~ 3.20%, and the number of infected people was 3 million. 2.30% ~ 25.00% patients with Taenia solium are accompanied by cysticercosis parasitism due to their own infection. The disease is often prevented by chemotherapy drugs such as praziquantel, albendazole and mebendazole, but long-term use of chemotherapy drugs has certain toxic and side effects. And it is easy to develop drug resistance. At present, genetic engineering vaccines of Taenia solium can be roughly divided into three types: recombinant antigen vaccine, nucleic acid vaccine and synthetic peptide vaccine, and great progress has been made [2].

appearance

The adult is leucorrhea, with a total length of 2m-4m and 700- 1000 limbs. Worms have three parts: head, neck and joint. The head segment is spherical with a diameter of about 1 mm. The center of the cephalic segment is the parietal bone. There are 25 ~ 50 small hooks on the coracoid process, which are alternately arranged inside and outside, and there are 4 round suckers under the coracoid process. These are accessory organs adapted to parasitic life. Live tapeworms are attached to the intestinal mucosa with suckers and hooks. Behind the cephalic segment is the neck, which is slender and knotless and has no obvious boundary with the cephalic segment. It can continuously produce segments through transverse division, so it is also the growth area of tapeworms. The closer to the neck, the younger the segment, and the wider and more mature the segment near the back end. According to the maturity of reproductive organs in a segment, it can be divided into three types: immature segment (INM mature segment), mature segment (mature segment) and pregnant or grave segment. Immature segments are wider than longer, and the internal structure has not yet developed. The mature part is almost square with male and female reproductive organs. Pregnant eggs are rectangular and almost completely filled with uterus.