Psoriasis has brought us endless pain and endless troubles to our lives. So what factors lead to psoriasis in life? The following small series will give you a detailed introduction, hoping to help you.
First, the mental state is not good
In daily life, bad mental state can also cause psoriasis. Among them, the onset or recurrence of psoriasis is often related to neurological and mental factors. Patients should remove their ideological concerns, establish confidence in overcoming the disease, be optimistic and cheerful, and avoid excessive emotional tension and anxiety. Patients should strengthen their physique and pay attention to prevent colds and tonsillitis, because bacterial and viral infections often cause the recurrence of psoriasis.
Second, excessive smoking and drinking.
In daily life, excessive smoking can also cause psoriasis. Patients should not drink alcohol, including all kinds of alcohol, even a small amount of beer. Drinking alcohol will pose a threat to the health of patients with psoriasis, which may lead to the onset of psoriasis.
Third, traumatic infection.
Traumatic infection in daily life can also cause psoriasis. In daily life, we should try to avoid all kinds of physical and chemical injuries, such as burns, frostbite, chemical burns, animal or insect bites, scratches, acupuncture, hair dyeing, contusion and so on. , so as not to induce the disease.
Patients should receive regular treatment, do not abuse drugs, and do not use external drugs with strong irritation in acute stage, so as not to stimulate the condition. After the skin lesions subside, they should not stop taking drugs immediately, and should continue to consolidate treatment for a period of time.
The above introduces the factors that cause psoriasis in daily life, and I hope to stay away from these factors as far as possible in daily life, so as not to get psoriasis and bring serious harm to myself.
Other factors
1, genetic factors
It is a polygenic genetic disease in which genetic factors and environmental factors interact.
2. Immune factors
Now medicine believes that psoriasis is a disease caused by immune disorder.
3. Infection factors
Studies have confirmed that streptococcal infection, staphylococcus aureus infection and fungal infection are related to psoriasis, but it is not clear whether viral infection is related to psoriasis.
4. Endocrine factors
Pregnancy can make the skin lesions disappear or alleviate, and it can also aggravate the skin lesions. Endocrine diseases such as thyroid diseases and diabetes have no obvious effect on the condition.
5. Mental factors
Patients may have neuropsychiatric changes, which may aggravate the existing skin lesions.
6. Living habits, drug factors and environmental factors
The study found that getting wet, infection, drinking, taking medicine and mental stress are the main risk factors of psoriasis.
Drugs that may induce or aggravate psoriasis include β 1 receptor blockers, non-steroidal anti-inflammatory drugs, lithium salts, antimalarials, tetracycline, calcium channel blockers, metformin, interferon α and so on.
Environmental factors are related to the age of onset, and season and climate have an influence on the onset and recurrence of psoriasis.
Psoriasis prevention
1, to prevent cold and damp.
2. Maintain emotional stability.
3. Prevent infection and avoid fatigue.
4. Prevent food or drug allergies.
Psoriasis treatment
1, external drug treatment
Mild protectants (such as 10% boric acid ointment and zinc oxide ointment) and corticosteroids should be used in acute phase. Drugs with strong effects, such as keratin promoters and immunosuppressants, can be used in the stable period and the regression period, but the concentration should be low. When the skin lesion area is large, it should be used in a small area first.
Keratin promoter
It can improve local microcirculation, inhibit RNA synthesis and reduce mitosis. Tar (5% ~ 10% black bean fraction, coal tar, pine fraction or bran fraction), 5% ~ 10% sulfur, 5% salicylic acid and 0.1%anthracene can be made into ointment or cream.
The latter two are highly irritating, and the face and mucosa are forbidden, so patients with liver and kidney diseases should use them with caution. Tar and aspirin can be used in combination with corticosteroids or ultraviolet rays.
Corticosteroid preparation
Can be made into cream, ointment or solution, coated or packaged. Single drug treatment, that is, twice a day, or intermittent treatment, twice a day until the focus subsides more than 85%, can be changed to continuous external use for three times every weekend, with an interval of 12h, that is, 8: 00 am on Saturday, 8: 00 pm on Sunday, a total of 1 time. This method can avoid drug resistance and rebound. Prednisolone plus 1% procaine solution can be injected into or below a few plaque lesions.
Vitamin D3 derivative
These substances are active metabolites of vitamin D3 or artificially synthesized, mainly calcipotriol, and their mechanism of action is to inhibit the growth and differentiation of keratinocytes.
External use has a good effect on plaque psoriasis, and it is not easy to rebound after drug withdrawal. The main side effects are itching, burning sensation, dryness and desquamation. This drug can be used as the first choice for mild to moderate psoriasis.
Retinoic acid drug
Commonly used are 0.025% ~ 1% tretinoin ointment, cream or gel for external use twice a day. Thick skin lesions can be given small packets. The main side effect is irritation.
At present, the third generation tazarotene retinoic acid gel is commonly used, with receptor selectivity, once a day/kloc-0 times, which is suitable for patients with psoriasis vulgaris. The side effects are; Burning sensation, erythema, itching, combined with glucocorticoid can improve the curative effect and reduce irritation.
Other preparatory work
Commonly used are1:20000 ~ 1: 1000 mustard gas,1:1000 nitrogen mustard, 0. 1% erythromycin,10% ~.
2, oral medication
Aromatic retinol
It can normalize keratinization, regulate epidermal proliferation and differentiation, and regulate inflammation and immune response. Can be used for pustular psoriasis, arthropathy psoriasis, erythrodermic psoriasis and other psoriasis vulgaris with ineffective treatment.
Etrulatate and avermectin have the best effect. See the general introduction for usage and side effects. Then PUVA combined with PUVA (photochemical therapy) can improve the curative effect and reduce the total amount of PUVA treatment. It can also be used in combination with immunosuppressants.
Adrenal corticosteroids
Only erythroderma or arthropathy and generalized pustular psoriasis can be used when other treatments are ineffective.
Immune inhibitor
There are methotrexate and hydroxyurea. These drugs are effective in time, but they are easy to relapse after withdrawal, and have great side effects, such as leukopenia, gastrointestinal reaction, liver and kidney damage, etc., and can induce malignant tumors.
For erythroderma, generalized pustule, arthropathy and other severe psoriasis vulgaris with poor therapeutic effect, it can be considered.
antibiotic
Penicillin and cephalosporin can be used for punctate psoriasis, and thiamphenicol (0.5 ~ 1.0g per day) can be used for pustular psoriasis.
immunomodulator
Levamisole was taken daily 1.50mg for adults, and intermittently for 4 days every week for 3 days, lasting 1 ~ 3 months. Transfer factor and thymic factor d can also be used.
Venous occlusion therapy
For patients with acute progressive erythroderma, intravenous injection or intravenous drip of procaine can be used (see general introduction for methods).
other
Use Agkistrodon halys antithrombotic enzyme (0.5~0.75g) and 5% ~ 10% glucose injection (250~500mL), and reduce the dosage as appropriate,/kloc-0 once a day, with 30 days as 1 course of treatment.
The use of 8- bromocyclic adenosine monophosphate in China has a good effect on psoriasis, especially pustular psoriasis. In addition, some non-specific stimulation therapies, such as fever therapy, vaccine therapy and oxygen therapy, can be tried according to the specific situation. Narrow-band UVB is effective and safer than PUVA.
Step 3: physical therapy
Bath therapy (hydrotherapy)
There are sulfur bath, bran bath, tar bath, mineral spring bath and Chinese medicine bath.
Ultraviolet radiation therapy
Single use or combination of oral administration and external use, or external use of tar drugs plus water therapy after phototherapy (Gokman triple therapy) or external use of 1% ~ 3% G Lin ointment for 5 ~ 20min before UVB irradiation (Ingram therapy). Suitable for patients at rest or in winter. Narrow-band UVB is effective and safer than PUVA.
Photochemical therapy (PUVA)
Oral or topical 8- methoxypsoralen (8-MOP) followed by PUVA irradiation is suitable for intractable cases that are ineffective in other therapies. The treatment area should not be too large, and it usually needs to be treated for about 20 times. During the treatment, patients should wear goggles to prevent cataracts and be alert to the occurrence of skin cancer. Light sensitive person, severe organic diseases, children and pregnant women are prohibited.
4, Chinese medicine treatment
According to its main symptoms, it can be divided into the following three types for treatment.
Blood-heat type
Corresponding to the acute progressive stage, the treatment should focus on clearing heat, cooling blood and promoting blood circulation, and Liang Xue Siwu Decoction or Salvia Miltiorrhiza, Lithospermum, Radix Paeoniae Rubra, Flos Sophorae Immaturus, Lalang Grass Rhizome, Radix Rehmanniae and Caulis Spatholobi can be used.
Blood stasis type
It is advisable to promote blood circulation, remove blood stasis and promote qi, which can be modified by Xuefu Zhuyu Decoction.
Blood dryness type
It is advisable to nourish yin, nourish blood and moisten dryness, and can be treated with Radix Asparagi, Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Fructus Lycii, Honeycomb, Radix Rehmanniae, Rhizoma Smilacis Glabrae, Caulis Spatholobi, etc. People with blood deficiency can also be treated with medlar.
5. Off-site treatment
Exercise more to enhance immunity. Change clothes frequently and keep your skin clean.
Conclusion: The above is the whole content of the article on psoriasis treatment brought by Bian Xiao. Now you should know the harm of psoriasis. There are many factors that lead to psoriasis. As long as we pay attention to cultivate good living habits and eating habits in our daily life, diseases will naturally stay away from us.