category insert; Acaricide

acts as a veterinary drug. (1) sheep nitrochlorophenol is an ideal drug for expelling Fasciola hepatica, and the effective rate of oral administration of 3mg/kg is 93% ~ 1% for Fasciola hepatica adults. For immature worms, the smaller the age, the greater the dosage, such as 4mg/kg. The effective rate of 8-week-old worms is 58.4%, and that of 12-week-old worms is 1%. The effective rate of 8mg/kg was 92.5% for 4-week-old worms, 99.7% for 6-week-old worms, 99.7% for 8-week-old worms, and 16mg/kg was 1% for 4-week-old worms. Some people have carried out extensive clinical trials on nitrochlorophenol, and the effective dose of 12-week-old worms is 2.7mg/kg (the safety index of treatment is 4.4); 6-week-old worms were 6mg/kg (treatment safety index 2.); The body of the 4-week-old worm is 8mg/kg (the therapeutic safety index is 1.5). According to the above experiments, it is proved that the safe range of the effective dose of niclosan for immature worms is very low. In fact, the dose of 6mg/kg can cause adverse reactions in sheep, so it has no clinical practical significance for immature worms. (2) The repellent effect of bovine nitrochlorophenol on Fasciola hepatica is similar to that of Fasciola hepatica. The extermination rate of Fasciola hepatica adults in adult cattle was 98.74%, and that of calves was only 76% ~ 8%. Buffalo takes 1 ~ 3mg/kg orally, but the dosage of 3 mg/kg is not effective for yak. The anthelmintic rate of 1 ~ 12 mg/kg is 1%, and the dosage of 16 ~ 2 mg/kg is needed to drive out Fasciola hepatica children, but at this time, cattle have been poisoned and have no practical significance. Some clinical trials suggest that nitrochlorophenol may have some effect on the transitional larvae of Clonorchis sinensis, because the physical condition of the affected animals is obviously improved after medication. (3) The oral dosage of 3 ~ 6 mg/kg for pigs can drive out Fasciola hepatica adults by nearly 1%, and animals are well tolerated.

nitrochlorophenol is a special drug for treating Fasciola hepatica in cattle and sheep. The drug is absorbed in the intestine orally and excreted slowly. The therapeutic dose is 3mg/kg orally, and the toxic dose for animals is 3 ~ 4 times of the therapeutic dose. The anthelmintic mechanism of nitrochlorophenol is to inhibit succinate dehydrogenase in the tricarboxylic acid cycle, so that ATP production in the body is reduced and aerobic metabolism of sugar is blocked, resulting in the damage of important organs such as heart, liver, kidney and brain due to insufficient oxygen supply, especially brain tissue, which is characterized by brain edema, central nervous system damage and optic nerve damage. Several cases of oral nitrochlorophenol poisoning rarely reported in China eventually died of respiratory failure. The clinical manifestations of poisoning are not specific, and there is no specific detoxification drug, so the mortality rate is high. It is necessary to strengthen the management of such drugs to avoid taking them by mistake, and once they are taken, they should be highly valued. In this case, the oral dose is far greater than the toxic dose, so the disease progresses rapidly, the symptoms appear early and severely, and the patient has a history of drinking, which may accelerate the absorption of nitrochlorophenol. There are several lessons in the process of treating this patient: ① Lack of understanding of nitrochlorophenol poisoning, and insufficient attention when the patient has mental symptoms, hypoxemia and respiratory failure; ② Due to the patient's reasons, he failed to thoroughly lavage his stomach at the first time, and failed to perform blood purification and ventilator-assisted respiratory therapy as soon as possible.