Toads are poisonous amphibians that secrete toxins as a means of protecting themselves. Toads have large bumps on the surface of their bodies, and these bumps are their sebaceous glands, all of which can produce toxic fluids. There are several sebaceous glands spread across the surface of the toad's body, most of which are not particularly large, the largest being their post-auricular glands, which are very visible and which secrete the most toxins.

Toads eject toxins when they encounter a threat from a natural predator. However, they do not normally eject toxins easily, and only do so in life-threatening emergencies

Humans also need to be careful when encountering toads, as they may also eject venom onto humans. Toads are generally fine if they don't feel threatened by humans who don't actively approach them, but if they are approached or captured by humans, they will perceive humans as a threat to their lives and will spray venom to protect themselves. The toads' venom is also harmful to humans, so they need to be careful

The toads are poisonous animals, but their main natural enemy is not humans. Therefore they are generally not particularly hostile to humans.

If humans don't actively provoke them, they won't bite or attack them.

However, self-defense is the instinct of all animals, and when humans commit certain acts that threaten the toads' survival, the toads will defend themselves, possibly by biting or releasing venom, which can also be harmful to humans.