Aloe emodin, the antibacterial active ingredient of rhubarb, is a chemical substance with orange needle-like crystals (toluene) or khaki crystal powder. It can be extracted from aloe, and has antitumor activity, antibacterial activity, immunosuppressive effect and laxative effect. Now it is widely used as a raw material for medicines and cosmetics.

Extended data:

Efficacy of aloe-emodin:

1. Relaxation: Aloe emodin in aloe can increase the moisture in the intestine, soften the stool and help people defecate better.

2. Prevention of frostbite: Wash and juice fresh aloe in winter, and apply aloe juice on frequently frostbitten parts, which can prevent frostbite.

3. Treatment of chilblain: Aloe emodin can be taken orally or used externally to treat hemorrhoids. When taken orally, mix boiled water with fresh aloe juice for drinking; For external use, after bathing, apply fresh aloe to hemorrhoid area and stick to it to promote the recovery of the disease.

Pharmacological efficacy:

1. Description of antitumor activity

In recent years, scholars at home and abroad are very interested in the anti-tumor effect of aloe-emodin The main anti-tumor activities are concentrated in neuroectodermal tumors, liver cancer, lung squamous cell carcinoma, skin Merkel cell carcinoma, gastric cancer, leukemia and other tumors. Aloe emodin can inhibit P388 leukemia cells and prolong their survival time. One of its mechanisms is to inhibit the biosynthesis of DNA, RNA and protein in cancer cells.

2. Antibacterial activity

Aloe emodin has inhibitory effects on staphylococcus, streptococcus, diphtheria, Bacillus subtilis, anthrax, paratyphoid and dysentery at the concentration of 1.5 ~ 25mg/ml, among which staphylococcus and streptococcus are the most sensitive, and the effective inhibitory concentration is 15-25ug/ml. The inhibitory concentrations of Staphylococcus aureus 209P, Escherichia coli and Shigella flexneri in vitro were 7.5mg/L and 600mg/L, respectively, and their antibacterial effects were bacteriostatic rather than bactericidal. One of its mechanisms is to inhibit the electron transfer in mitochondrial respiratory chain.

Aloe emodin has a strong inhibitory effect on nucleic acid and protein synthesis of Staphylococcus aureus. Aloe emodin has a strong inhibitory effect on clinical common anaerobic bacteria, among which it can inhibit the growth of common fragile bacteria by 90% ~ 100%, and its MIC is slightly higher than metronidazole. When the concentration is 8μg/ml, it can inhibit 76% ~ 9 1% anaerobic bacteria.

3. Immunosuppression

Aloe emodin can inhibit the production of biological antibodies, inhibit the removal of carbon particles, reduce the weight of immune organs, reduce the number of white blood cells and reduce the function of peritoneal macrophages. In vitro, the concentration of 100μg/ml significantly inhibited the incorporation of [3H]-TDR and [3H]Urd into lymphocytes.

4. Other functions

It has the functions of making hair soft and shiny, relaxing and refreshing, and removing dandruff.

In the mutagenic test of hamster fibroblasts, this product showed genotoxicity.

It can protect teak from termites.

References:

Baidu Encyclopedia-Aloe-Emodin