Dose usage
Intravenous injection or intramuscular injection: 40 ~ 250mg/ time, 1 ~ 6 times/day, dissolved in buffer or isotonic saline, and injected within 1 minute.
Matters needing attention
Long-term and high-dose use of corticosteroids can cause iatrogenic adrenocortical hyperfunction (Cushing's syndrome), which is characterized by full moon face, buffalo back, centripetal obesity, thin skin with purple stripes, muscle atrophy, osteoporosis, hyperglycemia, diabetes, hypertension, hypokalemia, female masculinity such as hair, long beard, amenorrhea and hoarse voice. (Metabolite androgen has weak effect). Withdrawal syndrome (myalgia, myotonia, joint pain, etc. ); Rebound phenomenon (if the dosage is reduced too fast or the drug is stopped suddenly, the original symptoms may appear or worsen rapidly); Iatrogenic hypoadrenocortical function (adrenocortical crisis): Endogenous glucocorticoid secretion is reduced due to negative feedback, even adrenal cortex atrophy. After stopping the drug suddenly, due to insufficient secretion of endogenous hydrocortisone, adrenocortical dysfunction may occur. In severe cases, adrenocortical crisis may occur, such as hypotension, hypoglycemia, coma and shock, and patients may suddenly faint. Hydrocortisone should be given first aid in time, 300mg 1 day and 200 mg 100 ~ 200 mg/day the next day, supplemented by fluid replacement, anti-shock and symptomatic treatment. When the condition improves, substitute therapy should be used. Patients with hyperthyroidism, hypertension, arteriosclerosis, edema, glaucoma, congestive heart failure, diabetes, ulcer, psychosis, epilepsy, osteoporosis, early pregnancy, puerperium, childhood growth, trauma, postoperative recovery, viroid infection, enzyme infection and active pulmonary tuberculosis are prohibited. Bacterial infection must be combined with large doses of effective antibacterial drugs. Eat a diet with low salt, low sugar and high protein, supplement potassium, calcium and vitamin D, take the medicine for more than 2 weeks, gradually reduce the dosage and slowly stop taking the medicine. ACTH 25u// day can be injected if necessary.
Specification of powder injection: 40mg, 50mg (with buffer 1ml).