The following is a part of the "Instructions for Radix Isatidis Granules". Please read it carefully and answer the following questions: Instructions for Radix Isatidis Granules OTC[ ingredients] Radix Isatidis and excipients. (1) Safe drug use refers to the correct selection of drug varieties, dosage and taking time according to the needs of the disease, so as to give full play to the best effect and try to avoid the adverse effects or harm caused by drugs to the human body. Drugs are divided into prescription drugs and over-the-counter drugs, which are drugs that can be judged, purchased and used by themselves without a doctor's prescription, referred to as OTC． for short. Most of these drugs are used for self-diagnosis and treatment of frequently-occurring and common diseases. Such as cold, cough, indigestion, headache, fever, etc. In order to ensure people's health, warnings are marked on the packaging labels and instructions for use of over-the-counter drugs in China, which clearly stipulate the use time and course of treatment of drugs, and emphasize that "if the symptoms are not relieved or disappear, you should consult a doctor". Prescription drugs are drugs that can only be prepared, purchased and used by a licensed doctor or an assistant doctor, referred to as RX. The use of prescription drugs should follow the doctor's advice. This drug is an over-the-counter drug.

(2) Over-the-counter drugs are mostly used for self-diagnosis and treatment of frequently-occurring and common diseases, such as colds, coughs, indigestion, headaches, fever, etc. In order to ensure people's health, the packaging labels and instructions for use of over-the-counter drugs in China are marked with warnings, which clearly stipulate the time and course of use of drugs. Over-the-counter drugs should also be taken in strict accordance with the drug instructions. Banlangen is an over-the-counter drug, and the instructions should be read carefully.

(3) It is wrong to say that traditional Chinese medicine has no side effects. All drugs have certain toxicity or side effects. If used reasonably, they can prevent and treat diseases, otherwise, they may be harmful to health.

(4)① According to the analysis, 30 experimental rats weighing about 300g were selected and treated as follows: Group A rats (15 rats) did not receive any treatment; Group B rats (15 rats) were put into the poisoning box and smoked twice a day, each time 16 rats, with an interval of 4 hours and 30 minutes each time, for 75 days. Therefore, in this experiment, the variable was smoking, with B as the experimental group and A as the control group.

③ Microscopic examination of lung tissue sections of the two groups showed that: Group A was normal; In group B, bronchiectasis, obvious emphysema, mucosal tissue necrosis and goblet cell proliferation were observed. The experimental conclusion was that long-term heavy smoking could cause respiratory diseases such as bronchitis, emphysema and lung cancer.

③ The control experiment is the only variable experiment, only the variables are different, and other conditions are the same and appropriate. Therefore, this experiment pays attention to the control condition of "same weight", and it is more scientific to pay attention to the conditions of "same variety", "same sex", "same diet" and "same health status".

Therefore, the answer is: (1) Xiaolan makes sense, because Banlangen is an over-the-counter drug;

(2) Before using Radix Isatidis granules, you should read the instructions carefully to understand the main components, indications, usage and dosage of the drug, so as to ensure the safety of medication;

(3) unreasonable; All drugs have certain toxicity and side effects.

(4)① Group B; Group a;

② Long-term heavy smoking can cause respiratory diseases such as bronchitis, emphysema and lung cancer;

③ Same breed, same sex, same diet and same health condition are reasonable.