Drug composition: ginseng, astragalus, cinnamon, licorice.
Additional and subtractive
Effects: Replenishing Qi and Yang.
Indications: Deficiency, timidity, lack of vitality, fatigue and weakness, lack of energy and fear of cold, acne in children, yang deficiency, blood deficiency, clear plasma, and inability to initiate grouting. Mainly used to treat myocardial infarction, anemia, chronic renal failure, etc.
Preparation method
Usage and dosage: Take 1 dose per day decoction in water.
Taboos for use: This prescription is derived from Sijunzi Decoction, with the addition of astragalus and cinnamon to replenish air and yang to treat various syndromes of insufficient vitality in children.
Adverse reactions
Clinical application 1. Leukopenia: Use this recipe to add or subtract: 10g white ginseng, 30g astragalus, 10g licorice, and 5g cinnamon. Decoction in water, take 1 dose daily, divided into 2 doses after breakfast and dinner. Take it 5 days a week, stop 2 days, and 4 weeks is a course of treatment. 120 cases of leukopenia were treated, including 51 males and 69 females; the youngest was 18 years old and the oldest was 68 years old; the duration of the disease was as short as half a year and as long as 9 years. Another 84 patients in the control group were given 420 mg of vitamin B, 20 mg of Lixue, and 0.22 g of inosine, 3 times a day, for 30 days as a course of treatment. Results: Among 120 cases, 68 cases were markedly effective (the total number of white blood cells increased to more than 4.O Classification improved and maintained for more than 1 month and symptoms improved); 9 cases were ineffective. The total effective rate was 92.5%, compared with 66.7% in the control group, P<0.01. (Note: ' represents superscript 9)
2. Chronic nephritis: Use this recipe with additions and subtractions: 5g ginseng (red ginseng), 20g astragalus, 2g cinnamon, and 3g licorice. Take 1 dose per day, divided into 2 times and decocted in water. No need to coordinate with western medicine treatment, the course of treatment is 30 days. Treatment of chronic nephritis; 18 cases, aged 20-50 years old; 11 males and 7 females. The diagnosis and staging criteria of chronic nephritis and renal insufficiency are found in "Internal Medicine" (Chen Haozhu, 3rd edition, People's Medical Publishing House, 1990, 449). The efficacy standards refer to the standards formulated by the State Administration of Traditional Chinese Medicine in 1987. Complete remission: symptoms and signs disappear, urine protein is qualitatively negative or 24-hour urine protein quantity is less than 0.2g, urine red blood cells disappear, and kidney function is normal. Basic relief: symptoms such as edema disappear, urine protein continues to decrease by more than 1/2, and kidney function is basically normal; partial relief: edema and other symptoms basically disappear, urine protein decreases by more than 3/4, and kidney function indicators are better than before treatment; invalid : Symptoms, signs, urinary proteinuria, and renal function remain unchanged or worsen. Results: 5 cases had complete remission, accounting for 27.8%; 3 cases had basic remission, accounting for 16.7%; 7 cases had partial remission, accounting for 38.9%; 3 cases had ineffectiveness, accounting for 16.7%; the total effective rate of treatment was 83.3%. Before treatment with Baoyuan Decoction, the patient's LPO was 4.89±1.85 μmol/L, which was higher than the control group by 3.36±0.59 μmol/L (P<0.001); the VE content was 4.27±1.84 μg/ml, which was lower than the control group by 7.03±0.69 μg/L. ml (P<0.05). After treatment, the patient's serum LPO was 3.76±1.49μg/L, which was lower than before treatment (P<0.05); the serum VE was 5.33±2.45μg/ml, which was not significantly different from that before treatment. There was a negative correlation between LPO and VE content in patients. It is suggested that this prescription has the effect of inhibiting lipid peroxidation.
Pharmacological effects: This prescription has the effects of enhancing the body's immune function, anti-shock, improving peripheral circulation, and promoting the proliferation of hematopoietic stem cells.
1． Enhance the body's immune function: (1) Enhance macrophage function. This formula has the effect of activating macrophages. In studies on inducing experimental endotoxemia, it was observed that this formula can promote the function of macrophages. Specifically, it can protect the clearance function of the reticuloendothelial system from endotoxin inhibition. , improve the clearance function of the reticuloendothelial system in rats with insulin-induced hypoglycemia; enhance the phagocytic ability of macrophages, and enhance the killing effect of macrophages on Don and BHK target cells. (2) Suppress autoimmune response. In the study of experimental autoimmune liver disease, it was found that Baoyuan Decoction can inhibit the inflammatory damage to the liver caused by immune responses, and can inhibit the production of specific antibodies by liver cells; mouse spleen cells were used for T cell colony culture, and Baoyuan Decoction The number of colonies in the group was higher than that in the liver disease group. It is believed that this prescription can inhibit the autoimmune reaction in the process of experimental autoimmune liver disease and prevent liver damage. (3) Enhance cellular immunity. A study on peripheral blood T cell colonies and T cell subpopulations in patients with chronic nephritis due to deficiency of both spleen and kidneys found that after taking Baoyuan Decoction for one month, the number of T cell colonies, positive rates of OKT3, OKT4 cells, and T4/T8 ratios were higher than before treatment. , the positive rate of OKT8 cells was lower than before treatment, and the inhibitory effect of the patient's serum on T cell colonies was weakened. It shows that this prescription can restore the balance of T cell subpopulation distribution, antagonize serum immunosuppressive factors, improve the proliferation and differentiation ability of T cells, and enhance cellular immune function.
Someone studied the relationship between deficiency syndrome and IL-2 and found that the activity of IL-2 in patients with kidney deficiency was significantly lower than that in normal people. It was thought that the synthesis of IL-2 was reduced, and the responsiveness of lymphocytes to IL-2 did not change significantly. After kidney-tonifying treatment, After treatment, IL-2 activity returned to normal and T cell proliferation was enhanced, which needs further study. (4) Enhance humoral immunity. This prescription can significantly reduce the activity of high serum IgE, and slightly improve IgG and IgM.
2. Improve cardiovascular system function: This prescription has a stable effect on improving the stroke rate and coronary perfusion flow rate per minute in dogs with acute myocardial infarction. For patients with coronary heart disease, the isotope 99 technetium product rate method was used to measure the cardiac ejection fraction and superior vena cava-pulmonary artery circulation time. The results showed that 1 hour after the patient took the medication, the cardiac ejection fraction increased significantly, with an average increase of 23.67%; The vena cava-pulmonary artery circulation time was slightly prolonged, with an average prolongation rate of 12.95%; there was no significant impact on electrocardiogram, blood pressure, and heart rate. It can be seen that this drug can significantly improve the heart pump function of patients with coronary heart disease, and significantly increase the heart's stroke ejection fraction when the heart rate remains unchanged, which is very important in the treatment of myocardial infarction and endotoxic shock. Another experiment showed that after patients with yang deficiency took this medicine, their peripheral pulsatile blood flow began to increase 10 minutes after taking the medicine, reaching the peak time of 43.3±12.6 minutes each time, and the finger temperature also increased at the same time, reaching the peak time. 52.5 ± 14.4 minutes, but there was no significant change in heart rate and blood pressure, indicating that while increasing the pumping function of the heart, this drug does not increase myocardial oxygen consumption, which is an advantage of this drug.
3． Improve blood system function: In a study on Baoyuan Decoction regulating the balance between coagulation and fibrinolysis, after mice were treated with LD100 endotoxin, Baoyuan Decoction was given once intravenous injection of 1.5 μl/100 μg, and 84.3% of the animals were treated with LD100 endotoxin. - No consumption of coagulation factors and secondary hyperfibrinolysis occurred for 24 hours, and the systemic Shwaltzman reaction was significantly reduced. In vitro culture of CFu-D was observed in patients with aplastic anemia before and after treatment. The yield of CFu-D in the Baoyuan Decoction group was significantly higher than that in the control group. A liquid containing 1g of Baoyuan Decoction crude drug per 1 ml was used to perform CFu on LACA mice. -D In vivo agar diffusion assay. The recipient mice were divided into a drug administration group and a control group. They were injected subcutaneously with 0.2 ml of Baoyuan Decoction or normal saline, each time a day for 5 days. The recipient mice were intraperitoneally injected with cyclophosphamide 0.3 mg/g 12 hours before the box was buried. The box was taken out 5 days after the box was buried, and CFu-D was counted under a microscope (>50 cells were considered to be 1 CFU-D). Results: The yield of CFU-D in the Baoyuan Decoction group was significantly higher than that in the control group, indicating that Baoyuan Decoction can promote the proliferation of hematopoietic stem cells.
4． Anti-shock: This prescription has a good anti-shock effect, and has a significant preventive and therapeutic effect on shock death in rats caused by E. coli endotoxin. The mortality rate in the control group was 61.8%, and that in the administration group was only 14.7%. The difference is very significant. . This drug has a very good protective effect on the drop in body temperature caused by endotoxin. The control group has a greater drop in body temperature and a slower recovery rate than the administration group. However, the results are exactly the opposite for animals with smaller body weight. In addition, this drug also has a significant protective effect on electrocardiographic changes caused by endotoxin. Compared with the control group, the QRS comprehensive wave width and P-R interval are significantly shortened, and the increase in T wave voltage is also reduced. Since the prolongation of the QRS comprehensive wave width is positively correlated with the damage to myocardial mitochondrial function, the above-mentioned effects of this prescription can reduce the damage to myocardial mitochondria, protect its oxidative phosphorylation ability, and provide a sufficient source of myocardial ATP to ensure heart pump function. Without damage, the mechanism of this drug against endotoxic shock may also be related to its improvement in peripheral circulation, increase in coronary flow and mild pressor effect. Another experiment showed that injecting sublethal doses of Escherichia coli endotoxin into the tail vein of mice caused experimental endotoxic shock. 79.8% of the animals in the control group died within 40 hours, and 50% of them died within 24 hours; Only 29% and 31.2% of the animals in the two administration groups died within 40 hours, and 20% of them died within 24 hours. The difference was very significant. When the mice were injected with the full lethal dose of endotoxin, the control group's death rate within 24 hours was very significant. The survival rate was only 1%, and that of the drug group was 33.3%. If the adrenal gland or pituitary gland is removed or animals are treated with large doses of chlorpromazine or pentobarbital, the anti-shock effect of this drug disappears, suggesting that its protective effect is achieved by enhancing the adrenal cortex function.
5. Enhance the Na+, K+-ATPase activity of red blood cells: Studies have shown that the Na+, K+-ATPase activity of red blood cell membranes in patients with renal failure is reduced. This method can increase the activity of this enzyme and affect membrane operation. Has a regulating effect. The ginseng in the prescription contains ATPase activity and has an enzyme activating effect on various tissues, thereby indirectly improving the environment of Na+, K+-ATPase. The action pathway of this prescription may mainly affect the activity of enzymes, and the effect on the quantity of enzymes is currently not known much.
6． Enhance kidney function: nephrectomized rats were orally administered 1.01g of Baoyuan Liquid per animal daily, or injected with 0.48g of Baoyuan Liquid per animal. Blood was collected from the retroorbital area at two weeks, five weeks, and seven weeks respectively, and the results of Scr and BUN in the blood were measured. , the two contents were significantly increased compared with the control group, and increased with the increase of medication time. Baoyuan decoction was used to treat 12 patients with chronic renal failure (CRF) due to deficiency syndrome. The effect of this prescription on the formation of erythroid colonies was observed, and the clinical efficacy was analyzed at the same time.
The results show that this prescription can reduce serum creatinine, and CRF serum can inhibit the formation of erythroid colonies in normal bone marrow. After treatment, this inhibitory effect weakened, the patient's Hb increased, and Hb was positively correlated with erythroid colony formation and negatively correlated with serum creatinine, suggesting that Baoyuan Decoction improves CRF anemia and increases the proliferation and differentiation ability of erythroid hematopoietic progenitor cells and reduces blood pressure. related to creatinine. Baoyuan Decoction was used to treat 18 cases of chronic nephritis. The changes in serum lipid peroxide (LPO) levels and vitamin E content were observed and the efficacy was analyzed. The results showed that the prescription could reduce urinary protein and serum creatinine LPO, increase serum protein and Hemoglobin content, the total effective rate was 83.3%. There was a negative correlation between the patient's LPO and vitamin E content, suggesting that this prescription has the effect of inhibiting lipid peroxidation.