No Oh, the new valley nattokinase product ingredients are food grade, are our usual common ingredients, nattokinase is the world's only one recognized non-drug thrombolytic agents, there are no toxic side effects, not to mention dependence, and nattokinase long-term use will activate the body's own thrombolytic mechanism, there is an old saying that, teach a person to fish better than to teach a person to fish, nattokinase is the latter, so there is no side effects and dependence! There are no side effects or dependence.