What is gout? Gout is a common and complicated arthritis. The most common joint is the first metatarsal (big toe), in addition to hand joints, knees and elbows. Its symptoms are joint pain, edema, redness and inflammation, and the onset is urgent and lasts for several days or weeks. The essential cause of gout is the increase of uric acid level in the body, and urate is deposited in joints and kidneys, which corrodes bones and leads to joint deformation.
Why gout is obese: Obesity is a risk factor for gout. Obesity will not only increase the risk of gout, but also lead to gout in obese patients at an earlier age. With the increase of body mass index, the incidence of gout increases obviously, and visceral fat is closely related to the occurrence of gout. Hypertriglyceridemia and obesity are both risk factors for gout. Obesity will lead to insulin resistance, and eventually lead to the reduction of uric acid excretion in the kidney through various channels. Obesity can increase the free fatty acids and the synthesis of uric acid by affecting the activity of xanthine oxidase.
Drinking: Excessive drinking is an independent risk factor for gout attack. Beer contains a lot of purine components, so the risk of gout is the greatest.
The possible reasons why drinking alcohol promotes the increase of serum uric acid level are as follows:
Ethanol stimulates human body to synthesize lactic acid, and lactic acid competitively inhibits renal tubular uric acid excretion. Ethanol can be degraded into adenosine monophosphate by increasing ATP, thus promoting uric acid production. Some wines, especially fermented drinks such as beer, will produce a lot of purines during fermentation. Long-term heavy drinking can promote the occurrence of China and even gout. Drinking alcohol is often accompanied by high purine food intake, which increases the risk of gout. Chronic alcohol-related liver disease caused by long-term heavy drinking is related to the increase of insulin level, which can inhibit insulin signaling pathway, increase the risk of insulin resistance, increase uric acid reabsorption and increase blood uric acid level. Hypertension: The serum uric acid level and the prevalence rate of HUA in patients with hypertension are significantly higher than those without hypertension. Hypertension is an independent risk factor for gout attack. Hypertension leads to microangiopathy, tissue hypoxia, and then the blood lactic acid level increases, inhibiting the secretion of uric acid in renal tubules, and finally leading to uric acid retention and HUA；; In addition, long-term use of diuretics, loop diuretics and thiazide diuretics in many hypertensive patients can promote the increase of serum uric acid level.
Purine-rich foods: Purine-rich foods (such as meat and seafood) can increase the risk of gout. Fructose is a carbohydrate that can increase the level of serum uric acid, promote the synthesis of uric acid and inhibit the excretion of uric acid. Therefore, a large intake of fructose-containing beverages can increase the level of serum uric acid.
How to prevent gout and pay attention to your body shape? Eat milk and eggs every day. Try not to eat pork, mutton, beef, chicken, fish and seafood. When you really want to eat, cook a small amount of lean meat, chicken or fish, eat meat without soup, and exchange eggs and milk. Eat more vegetables and fruits. Eat 1000- 1500 grams of vegetables and 4-5 fruits every day. Eat more lotus leaves, carrots, celery, cucumbers, eggplants, lettuce, pumpkins, zucchini, tomatoes, radishes, taro and potatoes. Drink plenty of water, not less than 2000 ml per day, but as much as 3000 ml. Taking a hot bath every day is to promote uric acid excretion. Avoid smoking and drinking. Do not eat coffee, strong tea or spicy food. The uric acid level of human body, like blood pressure and blood sugar, tends to increase with age. Most gout patients have been found to have a genetic tendency, but what really causes acute attacks is often some bad diet and living habits, such as overeating, which leads to overweight or obesity; Like to eat high fat (especially animal fat) and high protein food; Drink alcohol, especially when you are hungry, and eat some fried food at the same time; Tired, nervous, wet and cold, etc. Therefore, proper adjustment and control of diet can effectively prevent the acute attack of gouty arthritis.