Oryzanol mainly exists in coarse bran oil and its oil residue, and the content of oryzanol in rice bran layer is 0.3 ~ 0.5%. Oryzanol is dissolved in oil when rice bran is heated and pressed. Generally, the content of oryzanol in crude bran oil is about 2% ~ 3%. Its content is slightly different due to the climatic conditions of rice planting, rice varieties and the technological conditions of rice bran oil extraction. The content of oryzanol in rice bran in cold regions is higher than that in tropical regions. The content of oryzanol in crude oil was higher than that in low temperature pressing by high temperature pressing and solvent leaching. Among many vegetable oils, such as corn germ oil, wheat germ oil, rye bran oil and rapeseed oil, the content of oryzanol in crude bran oil is the highest, so oryzanol is mostly extracted from crude bran oil.

1, reducing blood lipid

Oryzanol Tablets (Figure 1)

The hypolipidemic effects of oryzanol are as follows: [1] (1) lowering serum total cholesterol and triglyceride content (2) lowering liver lipid (3) lowering serum lipid peroxide (4) preventing cholesterol from depositing on arterial wall (5) lowering gallstone formation index (6) inhibiting cholesterol absorption in digestive tract.

2. Anti-lipid oxidation

The oral dose of oryzanol was divided into 0. 1g/kg, 0.5g/kg and 1g/kg. The results showed that the lipid peroxide value of oryzanol group decreased by 19.2%, 210.6% and 210.4% respectively compared with the control group, and the antioxidant effect was obvious.

3. Safety toxicology analysis

The oral LD50 values of mice and rats were all more than 25g/kg, and there was no problem in subacute and chronic toxicity tests (30d, 90d, 180d). The maximum oral dose of 182d rats was 2.89g/kg. The highest oral dose for dogs was 100g/kg for 12 months, and other tests such as antigenicity and mutagenicity were normal.

4。 Improve autonomic nervous function

Oryzanol mainly improves autonomic nerve dysfunction, endocrine balance disorder and mental nerve disorder, so it has a certain regulatory effect on neurasthenia patients; At the same time, it can stabilize emotions, reduce anxiety and tension, and improve sleep; It is also commonly used in the adjuvant treatment of premenstrual syndrome and climacteric syndrome.

Edit this paragraph on clinical application.

Oryzanol mainly acts on the autonomic nervous system and secretory center of diencephalon, thus improving and regulating symptoms such as autonomic nervous dysfunction, endocrine disorder and mental disorder. Generally used for periodic psychosis, female climacteric syndrome, premenstrual tension, sequelae of concussion, vascular headache, autonomic nervous dysfunction and various neurosis. The usual dosage is 10 ~ 20mg, taken orally three times a day. Studies have found that oryzanol also has a good effect on other diseases. Clinical application is as follows: (1) Treatment of hyperlipidemia: oryzanol can inhibit the synthesis of cholesterol. However, the oral dose is relatively large, each time 100 mg, three times a day. After taking it for two months, the serum cholesterol and triglyceride have obviously decreased. (2) Treatment of angina pectoris: every time 10 ~ 20mg, three times a day, can obviously relieve symptoms. (3) Treatment of chronic gastritis: 50 ~ 600mg/ day (usually 300 mg), 2 ~ 4 weeks as a course of treatment, and 60.6% of people have achieved remarkable results. Some people also took large doses to treat abdominal distension, loose stool and belching after meals, and achieved satisfactory results. (4) Treatment of peptic ulcer: take 50 ~ 200mg each time, three times a day. After a trial of 46 patients, after 4 ~ 12 weeks of treatment, 34 patients achieved obvious curative effect and 9 patients improved their symptoms. (5) It can be used for beauty: oryzanol is called "beauty element" because it can reduce the fragility of capillaries, improve the microcirculation function of skin capillaries, and treat menopausal dermatosis, female facial desquamation eczema, tinea capitis, etc. The combination of oryzanol and vitamin E can also treat seborrheic alopecia, improve skin color and prevent chapped skin. (6) Treatment of multiple oral ulcers: 50 mg each time, taken orally three times a day, cured in 3-6 days, and can reduce the recurrence rate. (7) It can promote growth: the weight of teenagers who take cereal vitamins tends to increase day by day. Therefore, some people use it as one of the therapeutic drugs for children's developmental disorders. Oryzanol also has the effect of estrogen, which can treat ovarian hypoplasia. (8) Treatment of pica in children: oral administration of 10 mg three times a day for one week. It is believed that oryzanol can eliminate pica by regulating the functions of diencephalon and autonomic nerve. (9) Oryzanol is also commonly used in the adjuvant treatment of menopausal syndrome, which has a good effect on improving insomnia and anxiety in menopause. (10) oryzanol has a good function of nourishing nerves, can improve autonomic nerve dysfunction and endocrine balance disorder, and has a certain regulatory effect on neurasthenia patients; At the same time, oryzanol can stabilize mood, reduce anxiety and tension, and improve sleep. If insomnia lasts for a long time, patients over 1 month can cooperate with pure Chinese medicine Zhumian Bao to achieve rapid and ideal curative effect. (1 1) oryzanol has antiarrhythmic effect. It can reduce myocardial excitability by regulating autonomic nerve function. The lipid-lowering effect of oryzanol can also improve myocardial blood supply and sleep. Old friends are easy to wake up at night, so it is better to take oryzanol properly.