The same symptoms of sick chickens are depression, loss of appetite, rough feathers and emaciation. After invading the respiratory tract, there will be dyspnea and mucosal cyanosis. After invading the digestive tract, diarrhea will occur, and green or yellow-green loose stool will be discharged. After the joint is invaded, the tarsal joint and finger joint are swollen, and there are blisters or pustules of different sizes in and around the joint. When the eyes are invaded, the eyes are swollen with yellow and white exudates. When the brain is invaded, there will be neurological symptoms, which are manifested as head and neck tremors and angular arch inversion.

At the same time, Escherichia coli septicemia, hepatitis week, pulmonary cysticercosis, cellulose pericarditis, arthritis, panophthalmia, salpingitis, yellow-white granuloma of heart, pancreas and intestine may occur.