Efficacy of wild chrysanthemum: It functions to clear away heat, detoxify and reduce swelling. It has inhibitory effects on Staphylococcus aureus, Diphtheria bacilli, Streptococcus, Pseudomonas aeruginosa, Escherichia coli, and influenza virus. Clinically used: 1. Influenza and flu: 9g each of chrysanthemum, honeysuckle, forsythia, and burdock, 6g each of mint and licorice, decoction in water and take. 2. Acute purulent inflammation: 30-60g of fresh wild chrysanthemum flowers and leaves, simmered in water and taken frequently, and 30-60g of its flowers and leaves, simmered in water, washed externally or mashed and applied externally to the affected area. 3． Hypertension: 15g each of wild chrysanthemum and cassia, soaked in water instead of tea (especially suitable for liver-heat type hypertension). 4. Sore throat, scrofula, red and swollen eyes, etc.: It can be used in combination with other medicines. Wild chrysanthemum contains various active ingredients such as chrysanthemum alcohol, chrysanthemum lactones, amino acids, trace elements, etc. Its water extract has a significant protective effect on the cardiovascular system, can increase cardiac output, increase myocardial oxygen supply, and protect the normal physiological functions of ischemic myocardium. The water extract of wild chrysanthemum and the blue-green volatile oil extracted by steam distillation have killing or inhibiting activity against a variety of pathogenic bacteria and viruses. The water extract is effective against Staphylococcus aureus, Shigella dysentery, Escherichia coli, Typhoid bacilli, etc. Its inhibitory activity is stronger than that of volatile oil; it also has anti-inflammatory, antioxidant and analgesic activities. Pharmacological effects of wild chrysanthemum: 1. Effect on the cardiovascular system: Inject 1.5-2.0g (crude drug)/kg of the injection prepared by water extraction and alcohol precipitation of wild chrysanthemum into anesthetized cats, and the coronary flow will increase immediately. 93%, continuous observation for 40 minutes showed that the coronary flow rate increased compared with before administration, and there was a significant difference. The heart rate slowed down significantly after administration and was 12% lower immediately after administration than before administration. The difference in partial pressure of oxygen between arteries and veins was lower than before administration, indicating that myocardial oxygen consumption was reduced. For isolated rabbit hearts, after injecting wild chrysanthemum injection, coronary flow increased significantly and myocardial contraction amplitude decreased significantly. Significant dilation was also seen in rabbit kidneys and rabbit ear blood vessels after injection of wild chrysanthemum. Wild chrysanthemum preparation is used in dogs with experimental myocardial infarction or insufficient blood supply, which can significantly increase the uptake of cesium by the myocardium. Wild chrysanthemum decoction and alcohol-precipitated ethyl acetate extract, 80 mg/kg, intravenously injected into healthy anesthetized dogs can increase coronary flow by 49.6% and reduce coronary resistance by 45.8%. The effect lasts for about 10 minutes and slows down the heart rate. Blood pressure and total peripheral resistance decreased, cardiac output and stroke volume increased, and left ventricular work decreased, which were significantly different from those before administration. Wild Chrysanthemum Injection 2g (crude drug)/kg intravenously also has a significant protective effect on experimental myocardial ischemia in dogs, and the effect is greater than propranolol 1mg/kg. 2. Effect on platelet aggregation: Take the carotid artery blood of male rabbits to prepare rich plasma. Add 0.9ml to the aggregation tube. Add 0.1ml of wild chrysanthemum injection containing 1g (crude drug)/ml at room temperature. After leaving for 3 minutes, stir and incubate at 37°C for 2 minutes, add 5 μl of ADP, and use the regression method to calculate the ADP-induced rabbit platelet aggregation ability. Its inhibitory effect is 2.3 times that of Salvia miltiorrhiza and 3.2 times that of Codonopsis pilosula. Its 50% depolymerization dose is equivalent to 60% of Salvia miltiorrhiza and about 50% of Codonopsis pilosula. 3. Antihypertensive effect: Intraperitoneal injection or intragastric administration of wild chrysanthemum ethanol extract aqueous solution has obvious antihypertensive effect on non-anesthetized rats, anesthetized cats and anesthetized dogs. Intestinal injection of 50-100mg of the refined ethanol extract of wild chrysanthemum can reduce the blood pressure area percentage of anesthetized cats by -19 to -22% within 2 hours, without significant effects on heart rate and respiration. ; Give normal dogs 1 times by gavage 100-150mg/kg, or give chronic renal hypertensive dogs 100-200mg/kg daily for 3 weeks, and there will be a certain blood pressure reduction. Effect. Its antihypertensive characteristics are slow and lasting without serious toxic reactions. It is worth noting that the water extract hardly reduces blood pressure, indicating that the antihypertensive active ingredients exist in the ester-soluble part. Intraperitoneal injection of wild chrysanthemum extract aqueous solution still has a hypotensive effect on cats, and can inhibit the pressurizing reaction of blocking the common carotid artery. The test also proved that wild chrysanthemum has no obvious effect on ganglia and M-choline receptors, but it has anti-adrenergic effects. Intraperitoneal injection of anesthetized dogs does not reduce cardiac output, but the blood vessels dilate, the total peripheral resistance decreases, and the blood pressure decreases. Based on the above points, it is believed that the antihypertensive mechanism of wild chrysanthemum is not to reduce cardiac output or block sympathetic ganglia, nor is it through the vagal reflex mechanism, but through anti-adrenaline and dilation of peripheral blood vessels, and may also inhibit the vasomotor center. related. 4. Anti-pathogenic microorganisms: The minimum inhibitory concentration of wild chrysanthemum decoction against the virulent human Mycobacterium tuberculosis is 2.5mg/ml, and the minimum inhibitory concentration against Mycobacterium kansasii is 10mg/ml. Intracellular mycobacteria have no effect. The antibacterial principle is to change, destroy or disappear the bacterial cell wall and significantly destroy its ultrastructure. Wild chrysanthemum or wild chrysanthemum branches and leaves 1:5 decoction has the effect of inhibiting dysentery bacilli in the test tube, and the branches and leaves also have the effect of inhibiting typhoid bacilli. Wild chrysanthemum decoction also has inhibitory effects on a variety of other pathogenic bacteria. The MIC is approximately between 1:10-1:80. At high concentrations, it also has varying degrees of inhibitory effects on various skin fungi. The antibacterial effect of the whole wild chrysanthemum is stronger than that of the flowers, and the fresh product is stronger than the dried product. The potency will be reduced when heated (such as high-pressure sterilization). Wild chrysanthemum decoction also has the effect of delaying the pathogenesis of human embryonic kidney or human embryonic lung primary single-layer epithelial cells caused by ECHO11 virus, herpes virus and influenza virus Jingke 68-1 strain, but it has no effect on parainfluenza virus ( Sendai strain), adenovirus (type 3) and rhinovirus (types 17 and 20) are ineffective. In addition, wild chrysanthemum also has an inhibitory effect on Leptospira in test tubes. There is no obvious difference between different bacterial types, and the water decoction is stronger than the alcohol-soaked preparation. 5. Promote the phagocytosis function of leukocytes: In vitro tests, wild chrysanthemum decoction at a concentration of 1: 1280 can promote the phagocytosis of Staphylococcus aureus by human leukocytes, but its water decoction has no such effect. 6. Other effects: Wild chrysanthemum water decoction and alcohol precipitation extract, 50 or 150 mg, was intraperitoneally injected into mice poisoned by bungara or cobra venom. Compared with the control group, the mortality rate was reduced; but for sharp There is no therapeutic effect on mice poisoned by viper venom.