Low HbA2 is the manifestation of α thalassemia, but it cannot diagnose thalassemia (because iron deficiency may also cause this change). This means that the engine is broken and the car cannot run, but it doesn't necessarily mean that the engine is broken. It is suggested to carry out genetic examination of thalassemia to exclude/diagnose thalassemia. At the same time, serum iron and ferritin should be checked (unless young people are less likely to be iron deficient). As for the family genetic history, most poor patients have mild illness and mild symptoms, so they won't know without examination. Therefore, many thalassemia patients also say that they have no family history. In fact, no one in the family has found it. A genetic history will aggravate the suspicion of thalassemia, but no obvious genetic history will not alleviate the suspicion of thalassemia.

If the HbA is above 95%, HbF is normal (if tested), and there are no other hemoglobin variants (such as HbH), even α thalassemia is mild and will not have much impact on you. However, if you are diagnosed with alpha thalassemia and have not given birth, your spouse should thoroughly check whether you have thalassemia before or at the beginning of pregnancy (whether you are male or female). If you have given birth and have no plans to continue, then your child needs to be tested for thalassemia.