Haff's disease, namely Haff's disease. It refers to the unexplained rhabdomyolysis syndrome that occurs within 24 hours after the patient eats aquatic products. The disease first occurred in 1924 in Haff Bay, Baltic Sea. Later, it was reported in the Mediterranean, the United States, Brazil and China in 2000. In 20 10, the patients with rhabdolysis syndrome associated with eating crayfish were found in Nanjing, which had similar epidemiological characteristics and clinical manifestations to Haff, and were also confirmed as HAFF disease by medical experts.

Most of the causes of Huff's disease are unexplained rhabdomyolysis syndrome within 24 hours after eating aquatic products. The clinical manifestations are muscle soreness with increased serum creatine phosphokinase and myoglobin. Some patients have soy sauce color urine, most of them have good prognosis, and some serious patients will have acute renal failure. Most patients quickly recovered to normal, and only a few serious patients died. In the following nine years, about 1000 patients were found in the same season and the same area, and it was found that all these patients were related to eating freshwater fish, including freshwater cod, eel and pike.