2 English reference yuanhu zhitong tablets [Chinese Medicine Terminology Examination Committee. Chinese Medicine Terminology (2004)]
Yuanhu zhitong pian [Terminology Committee of Traditional Chinese Medicine. Terminology of Traditional Chinese Medicine (2004)]
3 national essential drugs and Yuanhu Zhitong tablets related to the national essential drugs retail guidance price information
Serial number essential drugs
Directory serial number drug name dosage form specification unit retail refers to
Remarks on the price category 760 62 Yuan Hu Zhitong Tablets 50 tablets (sugar-coated) box (bottle) 4.4 Chinese patent medicine part * (refers to the dosage of 4 ~ 6 tablets at a time, Product specification for three times a day) 76 1 62 yuanhu Zhitong tablets 10 tablets (sugar-coated) box (bottle) 0.93 Chinese patent medicine part 762 62 yuanhu Zhitong tablets 12 tablets (sugar-coated) box (bottle)1./kloc-. Kloc-0/5 tablets (sugar-coated) box (bottle) 1.4 Chinese patent medicine part 764 62 yuan Hu Zhitong tablets 18 tablets (sugar-coated) box (bottle) 1.6 Chinese patent medicine part 765 62 yuan Hu Zhitong tablets 20 tablets (sugar-coated) box (bottle) .8 Chinese patent medicine part 766 62 Yuan Hu Zhitong tablets 24 tablets (sugar-coated) box (bottle) 2.2 Chinese patent medicine part 767 62 Yuan Hu Zhitong tablets 30 tablets (sugar-coated) box (bottle) 2.7 Chinese patent medicine part 768 62 Yuan Hu Zhitong tablets 36 tablets (sugar-coated) box (bottle) 3.2 Chinese patent medicine part 769 62 Yuan Hu Zhitong tablets 40 tablets (sugar-coated) (Bottle) 3.5 Chinese patent medicine part 770 62 yuan Hu Zhitong tablets 45 tablets (sugar-coated) box (bottle) 4 Chinese patent medicine part 77 1 62 yuan Hu Zhitong tablets 48 tablets (sugar-coated) box (bottle) 4.2 Chinese patent medicine part 772 62 yuan Hu Zhitong tablets 56 tablets (sugar-coated) box (bottle) 4.9 Chinese patent medicine part 773 62 yuan Hu Zhitong tablets 60 tablets (sugar-coated) box (bottle) 5.2 Chinese patent medicine part 774 62 yuan Hu Zhitong tablets 1 00 tablets (sugar-coated) box (bottle) 8.6 Chinese patent medicine part 775 62 Yuan Hu Zhitong tablets 20 tablets (film-coated) box (bottle) 2 Chinese patent medicine part 776 62 Yuan Hu Zhitong tablets 24 tablets (film-coated) box (bottle) 2.4 Chinese patent medicine part 777 62 Yuan Hu Zhitong tablets 36 tablets (film-coated) box (bottle) 3.5 Chinese patent medicine part Pain tablets 48 tablets (film-coated) box (bottle) 4.7 Chinese patent medicine part 779 62 Yuan Hu Zhitong tablets 60 tablets (film-coated) box (bottle) 5.8 Chinese patent medicine part 780 62 Yuan Hu Zhitong tablets 100 tablets (film-coated) box (bottle) 9.4 Chinese patent medicine part Note:
1, dosage form specifications marked with "*" in the remarks column in the table are representative products.
2. Specifications of dosage forms marked with "△" in the remarks column in the table, and other specifications of the same dosage form are temporary prices.
3. The dosage form specifications are indicated in the remarks column. The prices of other specifications in this dosage form are based on the same usage and dosage, and are calculated according to the Drug Price Comparison Rules.
4. The "honey pills" marked in the dosage form column in the table include small honey pills and big honey pills.
4 Summary Yuanhu Zhitong Tablet is a Chinese patent medicine, see Pharmacopoeia of the People's Republic of China (2000 edition) [1]. The main ingredients are Rhizoma Corydalis (processed with vinegar) and Radix Angelicae Dahuricae [2]. It has the effects of regulating qi, promoting blood circulation and relieving pain [1]. Used for stomach pain, hypochondriac pain, headache and menstrual pain due to qi stagnation and blood stasis [1].
Pharmacopoeia of the People's Republic of China (20 10 edition) records the pharmacopoeia standard of Yuanhu Zhitong Tablets.
The prescription is 445g of Rhizoma Corydalis (processed with vinegar) and 223g of Radix Angelicae Dahuricae [1].
Method: 1000 sugar-coated tablets [1] were made according to the tablet technology.
The efficacy and indications of 7 Yuanhu Zhitong tablets are regulating qi, promoting blood circulation and relieving pain [1]. Used for stomach pain, hypochondriac pain, headache and menstrual pain due to qi stagnation and blood stasis [1].
Usage and Dosage of 8 Yuanhu Zhitong Tablets Take 4-6 tablets orally each time, 3 times a day, or as directed by the doctor [1].
9 Source "Pharmacopoeia of the People's Republic of China" (2000 edition)
10 Pharmacopoeia Standard of Yuanhu Zhitong Tablets 10. 1 Name Yuanhu Zhitong Tablets
Yuanhu Zhitong Pian
10.2 prescription vinegar corydalis yanhusuo 445g and angelica dahurica 223g.
10.3 Prepare the above two ingredients, take Radix Angelicae Dahuricae 166g, and pulverize the remaining Radix Angelicae Dahuricae and vinegar Rhizoma Corydalis into coarse powder, soak in 60% ethanol for 24 hours, reflux extract twice, the first time is 3 hours, the second time is 2 hours, filter, combine filtrates, concentrate the filtrates into thick paste, add the above fine powder, make granules, and press.
10.4 characteristics This product is a sugar-coated tablet or a film-coated tablet. After the coating is removed, it appears brown to brown [3]; The smell is sweet and the taste is bitter.
10.5 identification (1) Take this product 10 tablet, remove the coating, grind it, add 50ml of methanol, perform ultrasonic treatment for 30 minutes, filter, add 5g of neutral alumina to the filtrate, shake it for several minutes, filter, evaporate the filtrate, add appropriate amount of water to the residue to dissolve it, and add concentrated ammonia test solution to adjust the pH value to 9 ~. Another reference medicinal material 1g of Rhizoma corydalis was taken, and 50ml of methanol was added. After ultrasonic treatment for 30 minutes, it was filtered, and the solution of reference medicinal material was prepared by the same method from "evaporating the filtrate to dryness". According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia I, 20 10 edition), 2 ~ 3 μ l of the above two solutions were absorbed and spotted on the same silica gel G thin-layer plate prepared with 1% sodium hydroxide solution, and n-hexane-chloroform-methanol (7.5: 4:1) was used as the developing agent. In the chromatogram of the test sample, spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials; After the iodine adsorbed on the plate was evaporated, it was examined under an ultraviolet lamp (365nm) and showed fluorescent spots of the same color.
(2) Take this product 10 tablet, remove the coating, grind it, add 20 ml of petroleum ether (60 ~ 90℃), perform ultrasonic treatment for 20 minutes, filter, and volatilize the filtrate to about 1ml as the test solution. In addition, 0.5g of Radix Angelicae Dahuricae was taken as the control medicinal material, and the control medicinal material solution was prepared by the same method. According to the test of thin-layer chromatography (appendix ⅵ b of Pharmacopoeia I, 20 10 edition), absorb each 10ul of the above two solutions, respectively spot them on the same silica gel GF254nm thin-layer plate, use petroleum ether (60-90℃)-diethyl ether (3: 2) as the developing agent, spread them out, take them out and dry them in ultraviolet light. In the chromatogram of the test sample, spots of the same color or fluorescent spots appear at the positions corresponding to the chromatogram of the control medicinal materials. [3]
10.6 the inspection shall comply with the relevant provisions under tablets (appendix I d of Pharmacopoeia 20 10).
10.7 content determination 10.7. 1 vinegar corydalis yanhusuo was determined by high performance liquid chromatography (appendix ⅵ d of Pharmacopoeia I, 20 10 edition).
10.7. 1. 1 Octadecylsilane bonded silica gel was used as filler for chromatographic conditions and system suitability test; Using acetonitrile as mobile phase A and 0:6% glacial acetic acid solution (adjusted to pH 6.0 with triethylamine) as mobile phase B, gradient elution was carried out according to the regulations in the following table; The detection wavelength is 280nm. The theoretical plate number should be no less than 6000 calculated by tetrahydropalmatine peak.
Time (minutes): mobile phase A(%) mobile phase B (%) 0 ~ 20 43 57 20 ~ 22 43 → 80 57 → 20 22 ~ 25 80 → 43 20 → 57 25 ~ 35 43 5710.7.1.2 reference substance.
10.7.10.3 preparation of test solution take 20 tablets of this product, remove the coating, weigh accurately, grind finely, take about 1g, weigh accurately, put it in a conical flask with a stopper, and add 50ml of mixed solution of concentrated ammonia solution and methanol (1:20) precisely. Weigh again, make up the lost weight with the mixed solution of concentrated ammonia solution and methanol (1:20), shake and filter, take 25ml of continuous filtrate, evaporate to dryness, dissolve the residue with methanol, transfer to a 5ml volumetric flask, dilute to scale with methanol, shake and filter, and take the continuous filtrate.
10.7.10.4 determination method Accurately suck 20ul of the reference solution and the test solution respectively, inject them into a liquid chromatograph, and determine.
The content of corydalis yanhusuo with vinegar in each tablet of this product is calculated as tetrahydropalmatine (C2 1H25NO4), which shall not be less than 75ug.
10.7.2 angelica dahurica was determined by high performance liquid chromatography (appendix Ⅳ D of Pharmacopoeia I of 20 10 edition).
10.7.2. 1 Octadecylsilane bonded silica gel was used as filler for chromatographic conditions and system suitability test; Acetonitrile-water (47: 53) was the mobile phase; The detection length is 300nm. The theoretical plate number should be no less than 6000 according to the imperatorin peak.
10.7.2.2 preparation of reference substance solution: take a proper amount of imperatorin reference substance, weigh it accurately, and add methanol to make a solution containing 40ug per 1ml.
10.7.2.3 preparation of test solution take 20 tablets of this product, remove the coating, grind, take about lg, weigh it accurately, put it in a conical flask with a stopper, add 50ml of methanol accurately, weigh it, perform ultrasonic treatment (power 250W, frequency 40kHz) 30 for 30 minutes, let it cool, weigh it again, and make up the loss with methanol.
10.7.2.4 determination method Accurately suck 10ul of the reference solution and the test solution respectively, inject them into a liquid chromatograph, and determine to obtain the product.
Each tablet of this product contains Radix Angelicae Dahuricae in terms of imperatorin (C 16H 14O4), which shall not be less than 50ug. [3]
10.8 function and indications for regulating qi, promoting blood circulation and relieving pain. Used for stomachache, hypochondriac pain, headache and dysmenorrhea due to qi stagnation and blood stasis.
10.9 Usage and dosage for oral administration. 4 ~ 6 tablets at a time, 3 times a day, or as directed by the doctor.
10. 10 specification (1) film-coated tablets? Weight of each tablet is 0.26g (2) The weight of each film-coated tablet is 0.31g.
(3) sugar-coated tablets (core weight 0.25g) (4) sugar-coated tablets (core weight 0.3g)[3]
10. 1 1 storage and sealing.
10. 12 Edition Pharmacopoeia of the People's Republic of China 20 10 Edition
1 1 drug description of yuanhu Zhitong tablets 1 1. 1 drug type Chinese medicine
1 1.2 Drug name: Yuanhu Zhitong Tablet
1 1.3 pharmaceutical Chinese pinyin Yuanhu Zhitong Pian
1 1.4 Ingredients Corydalis yanhusuo vinegar and Angelica dahurica
1 1.5 characteristics Yuanhu Zhitong tablets are sugar-coated tablets or film-coated tablets, and after removing the coating, they appear brown to brown; The smell is sweet and the taste is bitter.
1 1.6 yuanhu Zhitong Tablet has the functions of regulating qi, promoting blood circulation and relieving pain. Used for stomachache, hypochondriac pain, headache and dysmenorrhea caused by qi stagnation and blood stasis.
1 1.7 the usage and dosage of Yuanhu Zhitong tablets are taken orally. 4 ~ 6 tablets at a time, 3 times a day, or as directed by the doctor.
1 1.8 Precautions 1. The diet should be light and avoid alcohol and spicy, cold and greasy food.
2. Avoid anger and depression, and keep a good mood.
3. Those with serious chronic diseases such as hypertension, heart disease, liver disease, diabetes and kidney disease should take it under the guidance of a doctor.
4. Children, pregnant women, lactating women and the elderly and infirm should take it under the guidance of a doctor.
5. Those with severe pain should go to the hospital in time.
6. If the symptoms are not relieved after taking the medicine for 3 days, you should go to the hospital.
7. It is forbidden for people who are allergic to Yuanhu Zhitong Tablet, and should be used with caution for people with allergic constitution.
8. It is forbidden to use Yuanhu Zhitong Tablet when its properties change.
9. Children must use it under the supervision of adults.
10. Please keep Yuanhu Zhitong tablets out of the reach of children.
1 1. If you are using other drugs, please consult a doctor or pharmacist before using Yuanhu Zhitong Tablet.
1 1.9 drug interactions may occur if used together with other drugs. Please consult your doctor or pharmacist for details.
1 1. 10 Remarks