A chemical agent, menthol is extracted from the leaves and stems of peppermint, white crystals, molecular formula C 10 H 20 O, as the main component of peppermint and mentha piperita essential oil. In the world, India is the main producer of natural mint. Menthol and spearmint brain can be used as toothpaste; perfume; drinks and candies, etc. fragrance. In medicine as *** medicine, the role of the skin or mucous membranes, there is a cooling effect of itching; internal use can be used as a wind medicine for headaches and nose; pharynx; throat inflammation, etc.. Its ester is used in spices and drugs.

Basic introduction Chinese name ：Menthol Foreign name ：Menthol Other names ：Menthol Ice Indications ：Itchy skin and itchy dermatosis Properties ：Colorless acicular or prismatic crystals, etc. CAS No. ：89-78-1 Basic Information, Numbering System, Safety Information, Physicochemical Properties, Molecular Structure Data, Calculated Chemistry Data, Properties and Stability, Storage Methods, Main Uses, Preparation, From Citronellal,Manufactured from Thymol,Manufactured from Peppermint Oil,Identification,Drug Information, Basic Information Chinese Name: Menthol Chinese Alias: (+/-)-Menthol; Menthol; 2-isopropyl-5-methyl-cyclohexanol; Hexahydrothymol; DL-Menthol English Alias: Menthol; 2-isopropyl-5- methyl-cyclohexanol methyl-cyclohexanol; CAS No. 89-78-1 Molecular Formula: C 10 H 20 O Molecular Weight: 156.26500 Precision Mass: 156.15100 PSA: 20.23000 LogP: 2.43950 Numbering System CAS No.: 89-78-1 MDL No.: MFCD00001484 EINECS No.: 201-939-0 RTECS No.: OT0350000 BRN No.: 1902288 PubChem No.: 24901226 Safety Information Customs Code: 2906110000 Dangerous Goods Transportation Code: UN 1888 6.1/PG 3 WGK Germany: 2 Hazardous category code: R36/37/38 Safety Instructions: S36/37/39-S24/25-S36-S26 RTECS No.: OT0350000 Dangerous Goods Symbol: Xi Physical and Chemical Properties The product is a saturated cyclic alcohol obtained from the oil of thin He. Also known as menthol, menthol ice. Flammable, burns well, no smoke in burning. The product is colorless needle-like or prismatic crystals or white crystalline powder; there is a special aroma of peppermint, taste the first burning after the cool; ethanol solution shows a neutral reaction. It is very soluble in ethanol, chloroform, ether, liquid paraffin or volatile oil, and very slightly soluble in water. Molecular structure data 1、Molar refractive index：47.83 2、Molar volume（cm 3 /mol）：175.5 3、Isotonic specific volume（90.2K）：409.8 4、Surface tension（dyne/cm）：29.7 5、Polarizability（10 -24 cm 3 ）：18.96 Calculated chemical data 1、Hydrophobicity parameter calculated reference value（XlogP）：3 2、 Hydrogen bonding Number of hydrogen bond donors: 1 3. Number of hydrogen bond acceptors: 1 4. Number of rotatable bonds: 1 5. Number of isomers: 6. Topological molecule polar surface area (TPSA): 20.2 7. Number of heavy atoms: 11 8. Surface charge: 0 9. Complexity: 120 10. Number of isotopic atoms: 0 11. Number of defined atomic structure centers: 3 12. Number of undetermined atomic structure centers: 0 13. 13, determine the number of chemical bonding centers: 0 14, the number of uncertain chemical bonding centers: 0 15, the number of *** valence bonding unit: 1 Properties and Stability 1. The left-handed is colorless needle-like crystals. Soluble in ethanol and miscible with oil. Has a cool, fresh, pleasant minty characteristic aroma with sweet acrid air. Gives a cold sensation, the aroma is penetrating, but not long-lasting. The taste is also fresh, sweet and cool. 2. found in baking tobacco, flavored tobacco, and mainstream smoke. 3. Naturally occurs in peppermint oil, Japanese peppermint oil, and to a lesser extent in essential oils such as allspice. 4. ***There are 12 isomers. 5. Ordinary crystals have traces of liquid oil on the surface and very small amounts of nonvolatiles. Synthetic menthol is a mixture of various isomers. 6. There are some toxicity, *** and allergic reactions. Storage method This product should be sealed and stored in a cool place. Main uses 1. Menthol and menthol are used as the fragrance of toothpaste, perfume, beverage and candy. In medicine, it is used as *** medicine, acting on the skin or mucous membranes, it has the effect of cooling and relieving itching; internally, it can be used as wind-expelling medicine for headache and inflammation of the nose, throat and larynx, etc. Its ester is used in spices and medicines. Its ester is used in spices and medicines. In the world, China and Brazil are the main natural mint production garden, the annual output of peppermint oil have reached 2000-3000t. 2. Widely used in daily flavor, edible flavor, cigarette flavor. Generally 1100mg/kg in chewing gum; 400mg/kg in candy; 130mg/kg in baked goods; 68mg/kg in ice cream; 35mg/kg in soft drinks. 3. It has bactericidal and antiseptic effects. 4. Used as a special additive for therapeutic cosmetics. Used in eau de toilette, etc. It can also be used as the fragrance of toothpaste, perfume, beverage and candy. Used in candy, beverage, spice and medicine. Preparation Menthol oil and menthol are industrially extracted from peppermint by water vapor distillation and organic solvent extraction, the former has low extraction efficiency and the latter has the toxicity of organic solvent residue. The use of supercritical carbon dioxide from the peppermint extracted menthol (menthol), can eliminate the drawbacks of the above two methods. Its yield is about 5 times higher than that of water vapor distillation method and about 3 times higher than that of organic solvent method. The product maintains pure natural characteristics, good quality, high purity, no toxicity of solvent residue, easy to meet the export requirements, and has better competitiveness and can occupy the market. Menthol can be purified from natural mint crude oil or synthesized. Mentha piperita above ground (stems, branches, leaves and inflorescences) by steam distillation of the essential oil obtained from the family Labiatae is called peppermint crude oil, the rate of 0.5-0.6. There are a variety of methods to synthesize menthane. Manufacturing from citronellal Using the property that citronellal is easy to cyclize into isohumol, dextro citronellal is cyclized into levo-isohumol with an acid catalyst (e.g., silica gel), the levo-isohumol is separated, and levohumol is hydrogenated to produce levohumol. Its stereoisomer can be partially subjected to conversion to dextro-citronellal by thermal cracking and recycled. Manufacture from thymol Alkylation of m-cresol in the presence of aluminum m-cresol produces thymol. Catalytic hydrogenation yielded all four pairs of menthol stereoisomers (i.e., racemic menthol; racemic neomenthol; racemic isomenthol and racemic neoisomenthol). The isomers were isolated and optically split by distillation, elimination of the racemic menthol fraction, manufacture of esters and repeated recrystallization. The isolated levo-menthol esters are saponified to give menthol. Racemic menthol can be separated from the other three pairs of isomers by distillation, and the remaining mixture of isomers can be equilibrated into racemic menthol, racemic neo-menthol, and racemic isomenthol under the condition of thymol hydrogenation, with the ratio of 6:3:1, and the content of neo-isomenthol is so small that it can be ignored. From the above mixture, racemic menthol can be separated. Racemic menthol by benzoate saturated solution or its supercooled mixtures to levulinic ester inoculation crystallization, separated from the saponification, the pure levulinic menthol; do not want to dextrorotatory menthol and other isomers, and then according to the hydrogenation conditions of the equilibrium transformed into racemic menthol. Manufacturing from peppermint oil Crystallization of peppermint oil after freezing, centrifugation of the resulting crystals with a low-boiling solvent recrystallization of pure levo-menthol. After removing the crystallization of the mother liquor still contains menthol 40% to 50%, also contains a large number of menthone, by hydrogenation into a mixture of levo-menthol and dextro-neo-menthol. The part of the ester is saponified, and more levo-neo-menthol can be obtained by crystallizing, distilling or making its borate ester and then splitting off the other parts of the peppermint oil. Identification (1) Take 1g of this product, add 20ml of sulfuric acid to dissolve, that is, showing orange-red, 24 hours later precipitated colorless oil layer without menthol aroma (and the difference between muskol). (2) Take 50mg of this product, add 1ml of glacial acetic acid to dissolve, add 6 drops of sulfuric acid and 1 drop of nitric acid cold mixture, only pale yellow (the difference with muscimol). Drug Information Pharmacological Actions The product forms conjugates with glucuronic acid that are excreted in urine and bile, and various isomers bind to glucuronic acid in varying amounts. It produces a molecular degradation reaction in dogs and rats. It can exist as menthone metabolite. PropertiesThe product is extremely soluble in ethanol, chloroform, liquid paraffin or volatile oils, and very slightly soluble in water. Specific rotation: take this product precision weighing, add ethanol to make a solution of 0.1g per 1ml, determined according to law, specific rotation of -49 degrees to -50 degrees. Indications for external use for local pain, itching, headache, dizziness, mosquito bites; nose drops for cold and nasal congestion, inhalation or spray for laryngitis; oral can be stomach. Drug interactions are often combined with camphor to enhance the effect of itching. Usage and dosage: Apply externally on itchy skin, can be used several times a day. 0.02～0.1g, more into the tablets to be taken. It can also be used as spiritus or ointment for external application on the affected area. Preparation and specification menthol powder, ointment and tincture: 1% to 2%. Adverse reactions occasionally have local *** effect. Contraindications Infants and young children are prohibited. Storage: Sealed and kept in a cool place. Poisoning first aid due to menthol on the skin and eyes have *** effect and a certain degree of toxicity, a large number of use must wear good gloves and safety glasses. Inhalation: Transfer the poisoned person to a ventilated place and take general first-aid measures. 2、Intake into the eyes: Flush the eyes according to the general procedure, consult a physician if necessary. 3. Skin contact: Wash with water and soap. 4. Other: Consult a physician. Do not use on eyes or mucous membranes. The lethal dose for subcutaneous injection in rats is about 2g/kg body weight. The use of nasal drops or ointment containing this product in young children is dangerous and will cause defecation.