1. Toxicity: The LD50 of sennoside to mice is 1. 14 1g/kg.
2. Senna leaves sometimes cause abdominal pain, vomiting or aggravate the original intestinal inflammation (especially when the dosage is large).
3. It has been reported that after taking senna, facial numbness, dizziness, no feeling or itching during defecation, pain relief in trigeminal nerve distribution area to varying degrees, urinary retention, and malignant blood pressure changes after taking large doses of senna. The LD50 of sennoside in mice is 1.4 14g/kg, which is equivalent to 36.3g/kg of sennoside, which is more than 300 times that of clinical sennoside po treatment.
4. The urine routine, serum creatinine, urea nitrogen, alanine aminotransferase, jaundice index and electrocardiogram of 102 patients who took senna were examined before and after treatment, and no obvious abnormality was found.
Extended data
Senna leaf, Chinese herbal medicine name. This product is leguminous lobule, narrow leaf diarrhea or pointed leaf diarrhea.
1, narrow leaf diarrhea: before flowering, pick leaves, dry them in the shade, classify them according to size and quality, and pack them with hydraulic press.
2. Sharp leaf diarrhea: when the fruit is ripe, cut off the branches, take off the leaves, dry them in the sun, and package them separately according to the whole leaves and broken leaves. Indications: purging heat and stagnation. Treat heat constipation and abdominal distension.
3, "new ginseng tablets": clearing heat, benefiting intestines, and defecating.
4. "Modern and Practical Chinese Medicine": Treating food stagnation, chest fullness and constipation.
I. Distribution area
1, distributed in tropical Africa. Introduction and cultivation in Taiwan Province, Guangxi and Yunnan.
2. Distributed in Egypt. Introduction and cultivation in Taiwan Province, Hainan and Yunnan.
Second, growing habits
Originated in dry and hot areas. It only takes 3-5 months from sowing to flowering. The number of days when the average temperature suitable for growth is lower than 10℃ should be 180-200d, and the accumulated temperature during this period should not be lower than 4000-4500℃. In Yuanjiang County, Yunnan Province, which is dry and hot in China, the average annual temperature is 23.8℃ and the annual rainfall is 484.7mm, and the introduction grows well. The soil requires loose sandy soil or alluvial soil with good drainage, and the soil is slightly acidic or neutral.
Third, pest control.
1, Rhizoctonia solani, which is harmful to seedlings, should be sprayed with 1: 1: 15o bordeaux solution or 50% carbendazim 1000 times solution before or at the early stage of the disease. At the same time, pay attention to sowing in dry season, apply lime powder to improve soil pH and strengthen seedling management.
2. Leaf spot disease is harmful to leaves. It can be sprayed with 1: L: 100 bordeaux solution or 50% carbendazim 1000- 1500 times solution.
3. Papilio larvae harm branches and leaves and are controlled by natural enemies of Lepidoptera moth in Yuanjiang, Yunnan.
References:
Baidu Encyclopedia-Ye