Rumor:
Orlistat is known as the oil pill on the Internet, and many people say that it is the only safe weight loss pill, want to eat, no diet, no rebound. Is it true?
Discredited:
Olestat is a kind of lipase inhibitor acting in the gastrointestinal tract, mainly inhibiting gastric lipase and pancreatic lipase in the lumen of the small intestine, so as to inhibit the decomposition of the ingested fat, so that the undigested triglycerides are not absorbed by the body, and are directly excreted, so as to achieve the effect of controlling weight.
Safety
①Orlistat is available in 60mg and 120mg per tablet. Only the 60mg is approved for sale as an over-the-counter drug in the United States and South Korea, which means it does not require a doctor's prescription to purchase, while the 120mg requires a doctor's prescription. Domestic orlistat is primarily a Class A OTC and needs to be used under the direction of a pharmacist.
②In May 2010, the FDA released information warning that orlistat may cause a rare but serious risk of liver injury. In September of the same year, China's State Food and Drug Administration required a revision of the instructions to the original Orlistat instructions There have been occasional reports of allergic reactions to Orlistat. The main clinical manifestations were pruritus, rash, urticaria, angioneurotic edema, bronchospasm, and anaphylactic reactions. Rarely, there have been case reports of maculopapular rash, elevated hepatic transaminases and alkaline phosphatase, and rare cases of severe hepatitis and pancreatitis. A causal relationship has not been established between hepatitis, pancreatitis, and orlistatUpdatedFor the use of orlistat there have been rare reports of elevated aminotransferases, elevated alkaline phosphatase, and severe hepatitis with cases of liver failure, some of which have required liver transplantation or can be directly fatal. Rare allergic reactions to orlistat have also been reported, with the main clinical manifestations being pruritus, rash, urticaria, angioneurotic edema, bronchospasm, and anaphylactic reactions, with herpes major being rare. Post-marketing surveillance also found reports of pancreatitis.
3) UK Pharmacovigilance Agency 2014 Risk Alert: Orlistat may cause hyperoxaluria and oxalate nephropathy.
In summary, orlistat is not a perfectly safe drug.
Effectiveness
①Olestat can inhibit the absorption of triglycerides, but it cannot break down fats that have been synthesized in the body, and it can only block the absorption of 30% of fats. It is useless if no fat is consumed in the diet. And orlistat does not block the energy conversion of carbohydrates, proteins and other substances, so relying solely on orlistat to lose weight is not scientific.
②The core principle of weight loss should be lifestyle modification, which includes dietary adjustments, increased physical activity and related behavioral therapies. Medication is not the primary method of weight loss.
Uniqueness
Currently on the Chinese market, in addition to orlistat there are a number of prescription medications with weight reduction effects, such as the hypoglycemic drug metformin and liraglutide. Liraglutide is the main glucagon-like peptide 1 receptor agonist with hypoglycemic effect in the current market. It can act centrally through neuronal pathways in the hypothalamus to promote satiety. However, the use of hypoglycemic agents for weight loss purposes is not recommended.
Other
①Long-term use of orlistat can affect the absorption of fat-soluble vitamins, such as vitamins A, D, E, and K.
②Olestat also affects the action of other drugs. If taken with drugs such as amiodarone and levothyroxine, you need to consult your physician and pharmacist. The U.K.'s drug watchdog warned in 2014 that orlistat may reduce the absorption of HIV treatment drugs such as efavirenz and lopinavir.
3) There's also the problem that with orlistat, your asshole may leak a little oil from time to time. Although the oil drainage is visible, it is oil from food, do not believe that orlistat can break down body fat.
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