Purulent infection: mainly for staphylococcus aureus, streptococcus and other infected hair follicles caused by boils, carbuncles, this disease will be repeated again and again, if the treatment of the skin disease, ignoring the control of blood glucose, it is very easy to develop into a septicemia and endangered life. Fungal infections: tinea pedis, tinea cruris, tinea cruris, and tinea pedis caused by trichophyton; stomatitis, vaginitis, and bacillary adenitis caused by Candida, which are likewise good and bad and difficult to cure. Itchy skin: including generalized itching and limited itching, of which female vulvar itching is more common. The skin will be scratched constantly due to the itching causing the skin to be covered with scratches and bloody scabs, which will eventually lead to mossification. Anterior tibial pigmented spots: In patients with a disease duration of more than five years, there may be garden-shaped or oval atrophic light brown spots on the anterior side of the lower leg, which are caused by capillary rupture and deposition of iron-containing hemoglobin. Diabetic foot: high blood sugar leads to lower limb vascular and neurological lesions, once the skin is slightly broken and infected without timely perception or treatment, it will rapidly form ulcers and gangrene, and ultimately have to do amputation, resulting in a double blow to the patient's body and psychology, and the quality of life is greatly reduced, and even life-threatening in serious cases. Diabetic blister disease: seen in patients who have been ill for a long time and have poor glycemic control, characterized by transparent blisters of varying sizes on the epidermis of the end of the limb, containing bright plasma, which is similar to scalded blisters, and it will disappear on its own, but if it is rubbed, it may be infected secondary. Other clinical occasional: diabetic lipoid progressive necrosis, diabetic xanthoma, capillary fragility increased erythema, purpura, sclerosing skin edema.