Fructose needs to be transformed by the liver, the most powerful metabolic organ in the body, and then phosphorylated to enter the metabolic cycle of glucose. As an intermediate product of glucose, it can also be reversed back to the form of glucose, which is used as glycogen by the liver and temporarily stored. This process especially challenges the transforming ability of the liver. When fructose is ingested properly, the liver can cope with free conversion and burning fructose. If fructose is ingested too much, it will cause excessive conversion pressure on the liver.

Liver is not only the site of fructose conversion, but also the most active site of fat synthesis.

Different from excessive intake of glucose, the body can quickly release glucose into the blood and then use it by cells. This is what insulin does.

A large amount of fructose can only be trapped in liver cells, and fructose itself has no storage mechanism. Once you enter the liver cells, there is only one transformation outcome, and this transformation process will not stop because there are too many transformation products, that is, there is no negative feedback mechanism, and the liver cells will not tell you that you are too busy.

Liver cells desperately process fructose, so a large amount of fructose becomes triglycerides in cells, which is also the formation principle of nonalcoholic fatty liver. In this transformation process, liver cells will lose energy and get tired because of over-processing, so they have no strength to make protein.

The liver is really omnipotent, and it is also responsible for the synthesis of protein. The production line in protein will produce a large number of semi-finished adenosine monophosphate due to lack of energy. After some tossing, adenosine monophosphate will become notorious uric acid. Having said that, we are surprised to find that excessive consumption of fructose is also related to the increase of uric acid.

This is why for patients with hyperuricemia and even gout, doctors need to add a sentence besides telling them to reduce the intake of high-purine food, that is, to drink less sweet drinks. Excessive fructose will lead to the increase of uric acid after the production line in protein is closed, thus aggravating the metabolic disorder of uric acid.

Fructose becomes fat after continuous production, because it needs to be transported to transport fat away from liver cells-the legendary low-density lipoprotein LDL, which is responsible for transporting freshly baked triglycerides from liver cells to the blood, providing power for cells or being stored by fat cells. If there is too much fructose in the body, liver cells will become temporary storage places for fat.

Once you drink fructose-containing drinks as water every day, it is equivalent to giving liver cells triglyceride raw materials that they can never drink, so fatty liver becomes permanent fatty liver.

This shows that the harm caused by excessive fructose far exceeds the calorie excess itself.