Duodenalulcer (DU) is caused by excessive secretion of gastric juice and/or weakened defense function of duodenal mucosa, which leads to local inflammatory damage caused by digestion and corrosion of duodenal mucosa by gastric acid in gastric juice. In severe cases, it can damage submucosal blood vessels or penetrate intestinal wall muscle layer, causing bleeding or perforation.

Drug therapy:

1, gastric acid inhibition therapy: H2 receptor antagonist, proton pump inhibitor (PPI)

2, gastric mucosal protection and treatment: aluminum magnesium carbonate, aluminum phosphate, sucralfate, aluminum hydroxide, bismuth potassium citrate, colloidal bismuth pectin, etc.

3. Treatment of Helicobacter pylori (Hp) infection: The first treatment was the quadruple therapy of proton pump inhibitor+bismuth+two antibacterial drugs, and the course of treatment was 10~ 14 days, with an effective radical cure rate of 90%.

4. Treatment of ulcer related to non-steroidal anti-inflammatory drugs (NSAIDs): Stop taking NSAIDs and use anti-ulcer drugs. If you can't stop taking NSAIDs, it is recommended to use PPI in combination to prevent ulcers.

5. Treatment of non-Hp- non-NSAIDs ulcers: proton pump inhibitors are recommended.