Factors leading to premature ovarian failure:
Ovarian aging refers to the gradual decline of women's ovarian function with age, which is influenced by many factors such as heredity, environment and behavior, and finally manifests as menopause, which affects many systems of the whole body and leads to related diseases. Ovarian aging not only includes age-related "natural" ovarian aging, but also includes ovarian dysfunction caused by various pathogenic factors.
1, perennial malnutrition leads to ovarian atrophy, egg adhesion, premature ovarian failure and even menopause due to multiple eggs discharged at one time.
2. Hormone imbalance caused by irregular life all the year round leads to premature ovarian failure.
3, premature ovarian failure caused by too many zombie cells and less active cells in the body.
4. Pathological premature ovarian failure
France ENlivEN 2 1 (decoded 2 1) the principle of anti-aging and ovarian maintenance: the damage of aging ovary includes the decrease of the number and quality of follicles and the change of ovarian microenvironment. The number of follicles is mainly regulated by genes and endocrine hormones, and the decline of follicular quality is related to free radicals and antioxidant system, mitochondrial DNA mutation and deletion, telomere and telomerase changes, vascular factors and so on. The accumulation of active metabolites is an important factor leading to the decline of follicular quality. In laboratory and clinic, further research shows that ENlivEN 2 1 (decoded 2 1) activates various cell groups such as ovaries, replacing and renewing the original decline and aging of tissues and cells caused by aging or pathological factors, and realizing the recovery of functions of tissues and organs such as ovaries.
ENlivEN 2 1 cell nutrition can enhance the activity and original tolerance of ovarian tissues and organs, activate zombie cells, promote follicular growth, angiogenesis in follicular membrane and synthesis of sex hormones, stimulate luteolysis, make pregnant eggs in ovary grow healthily and fully, prevent female infertility caused by premature ovarian failure, and avoid the arrival of menopause caused by egg adhesion due to lack of physical nutrition.
Previous studies mostly focused on the basic unit of ovary-follicle itself, and often ignored the surrounding microenvironment. Although the changes of follicle itself, such as double-stranded DNA damage, mitochondria reduction and abnormal centromere protein expression, are important factors of ovarian aging, the development and maturity of follicle and the self-renewal and differentiation of stem cells are inseparable from the surrounding microenvironment, and the mutual dialogue and communication between them can determine the fate of follicle and stem cells and the functional state of ovary. Ovarian microenvironment consists of ovarian cells, extracellular matrix and cytokines. In the process of aging ovary, the changes of microenvironment are mainly manifested as changes of ovarian immune function, vascular atrophy, interstitial fibrosis of ovary and changes of cytokines. Among them, ovarian fibrosis is mainly manifested as thickening of ovarian capsule, increase of interstitial fibrous connective tissue and decrease or disappearance of follicles. Decoding 2 1 enliv EN 2 1 repair factor to repair microcirculation system, in which elastin and hyaluronic acid active peptide intensively repair ovarian aging cells, can increase tissue regeneration ability, help self-made recovery of aging and ovarian regeneration, increase the density of collagen fibers and elastic fibers, and accelerate the repair process of emergency repair of ovary and uterine wall. ENlivEN 2 1 can prevent infertility caused by premature ovarian failure and postpone menopause.
Does premature ovarian failure reduce estrogen? What symptoms will it cause? Estrogen is a hormone closely related to women, which is mainly produced by ovaries. Although estrogen is mainly related to the development of female puberty and reproductive cycle, it affects everything from bones to emotions. The decrease of estrogen may lead to various health problems and symptoms: 1. Menstrual cycle disorder. 2. It can prevent ovulation and infertility. 3. Estrogen can play a role in body weight and body fat storage. Gain weight. 4. Vaginal lubrication will decrease, causing sexual pain. 5. Estrogen deficiency and serotonin reduction lead to mood swings or depression. 6. Risk of urinary tract infection. 7. Bone loss may occur. 8. Hot flashes. 9, affecting the synthesis of hyaluronic acid in the body, causing dry skin.
The most important risk factor for low estrogen level is age. In fact, estrogen levels began to decline several years before menopause, and short telomeres are one of the characteristics of cell aging. The proliferation and development of granulosa cells and the quality of oocytes are closely related to telomeres. The slow proliferation and development of granulosa cells will lead to the lag of follicular development and the decrease of hormone level; Shortening the telomere length of oocytes will lead to infertility, abortion and other consequences. Telomerase plays a role in maintaining telomere length and chromosome stability. Telomerase expression activity is different in different cell states, and it is closely regulated in many aspects [fzl3zl. Telomerase activity is closely related to the periodic changes of estrogen and progesterone. The development of follicles is inseparable from the regulation of telomerase. With the development of follicles, telomerase activity gradually decreases, which will further lead to the decline of follicular quality and female infertility.
Last reminder: for women, it is especially important to maintain the uterus and ovaries if they want to have a healthy body and lasting beauty! Finally, I wish all women a healthy body!