Cortex Moutan can increase coronary blood flow, decrease cardiac output and reduce left ventricular work in anesthetized dogs. It has obvious protective effect on experimental myocardial ischemia for a long time and reduces myocardial oxygen consumption.
2, antihypertensive effect.
Intravenous injection of Cortex Moutan decoction (equivalent to 0.75 g/kg crude drug) has antihypertensive effect on anesthetized dogs, cats and rats. Paeonol and its decoction also have antihypertensive effect in acute animal experiments. Experimental hypertension (essential hypertension and renal hypertension) can be taken orally by dogs or rats, but the effect appears slowly, which may be due to the slow absorption of gastrointestinal tract.
3, the role of the central nervous system.
Paeonol has antipyretic effect on fever caused by oral typhoid and paratyphoid vaccines in mice, and reduces the body temperature of normal mice. Oral paeonol can inhibit the writhing and tail tenderness caused by intraperitoneal injection of acetic acid in mice, resist excessive exercise caused by caffeine, obviously prolong the sleep time of mice caused by cyclohexylbarbital sodium, and make the righting reflex disappear in large doses, which can obviously resist convulsions caused by pentylenetetrazol, strychnine, nicotine and electric shock. The site of action is the reticular structure of midbrain and thalamus.
4. Anti-inflammatory effect.
Paeonol can inhibit rat paw edema caused by dextran or acetic acid or carrageenan, inhibit the increase of capillary permeability in mouse abdominal cavity or guinea pig skin caused by acetic acid or 5- hydroxytryptamine, and inhibit the occurrence of stress ulcer in mice.
5. Bacteriostasis.
In vitro experiments show that Peony Decoction has a strong antibacterial effect on Bacillus subtilis, Escherichia coli, Typhoid Bacillus, Paratyphoid Bacillus, Proteus, Pseudomonas aeruginosa, Staphylococcus, Streptococcus hemolyticus, Pneumococcus and Vibrio cholerae, and has an obvious antibacterial effect on Shigella, Pseudomonas aeruginosa and Staphylococcus aureus, and its effective component is gallic acid.
6. Anticoagulation.
In vitro experiments of human platelets showed that both the aqueous extract of Cortex Moutan and paeonol could inhibit the formation of thromboxane A2 by arachidonic acid on platelets, and then inhibit platelet aggregation, which was due to the inhibition of arachidonic acid on cyclooxygenase reaction of prostate H2. The methanol extract of Cortex Moutan can inhibit the experimental thrombosis caused by endotoxin.
7, eating grams: peony skin avoids garlic. Garlic is pungent and smelly, and peony bark is bitter and bitter but slightly cold, with opposite nature and taste, and opposite medicinal properties. So you can't eat garlic when you eat Chinese medicine containing peony bark.
Peony bark avoids coriander. Peony bark has the functions of clearing away heat and blood, clearing away deficiency and heat, promoting blood circulation and removing blood stasis. Coriander is spicy and fragrant, and peony bark is bitter and bitter, slightly cold, which is contrary to sexual and medicinal properties. So you can't use it together.