Michael Schofield robbed a bank at gunpoint the day after he finished his last tattoo. Upon his arrest he admits to the crime very cooperatively, and as a result the judge agrees and sentences Michael to five years in Fox River Prison, a suburb of Chicago.

Michael is assigned to cell 40 in Building A. His roommate, Fernando Sucre, volunteers to introduce him to the prison's colorful cast of characters, but there is only one person Michael wants to meet: his brother, Lincoln Barrows, who has been sentenced to death. But getting close to Lincoln requires getting a job at the prison factory, which is in the hands of John Abbotts, a former gangster and today's prison sensation.

Michael tells visiting attorney Veronica not to spend time on his case, that Lincoln was framed, that he didn't murder the vice president's brother, and that if she's still thinking about her former romance with Lincoln, she should try to get to the bottom of it. As far away as Washington, D.C., Special Agents Hale and Clurman are concerned about Lincoln's death sentence, as Bishop Mike Morrow intends to get a reprieve for Lincoln.

Abstracts receives word from his men that someone knows the whereabouts of the witnesses who put him in prison, and in the prison's medical room, Dr. Sara discovers that Michael is reacting strangely to insulin injections, and Michael immediately asks inmate Sticky Notes to get him the medication he needs to disguise himself as a Type I diabetic.

Michael gets into the prison factory and meets his brother, Lincoln, who thinks an escape is impossible, and Michael shows him the secret hidden in the tattoos: the blueprints for the design of Fox River Prison.

Episode 2

Michael hints at a plan to escape to his cellmates, Westmoreland mocks him for trying to break out after three days in jail, and another crisis looms, with racial strife at Fox River Prison on the horizon.

Michael copies the words "Schweitzer Allen 11121147" from his arm tattoo and finds the screw with serial number 11121147, but the screw is snatched by the Backpack and given to his henchman, Maytag. Maytag. Michael tells Lincoln they will escape through the hospital, which is why he is disguised as a diabetic.

Tim Giles shows Veronica the videotape of the murder scene, and Veronica despairs as she sees that Lincoln did indeed raise his gun at the dead man in the car, but Lincoln explains that Stedman was already dead at the time, and that he didn't even pull the trigger. And Special Agents Hale and Clurman learned from Tim that Veronica was reopening the case.

Michael took the opportunity to approach Maytag during the prison riot to retrieve the screws, but Maytag was stabbed to death in the chaos, which "The Pack" blamed on Michael. Michael sharpened the screw into a screwdriver from the pattern on the tattoo and used it to unscrew the nut on the lavatory equipment.

Michael passed his diabetes test with the drug, but Dr. Sara was puzzled by the look of relief on his face when he was told he was diabetic. On the way back to his cell, prison guard Berwick reckons he left him with Abbotts' gang. Abbotts ordered Michael's toes to be cut off in order to torture the witness about the whereabouts of Fibonacci.

Episode 3

Dr. Sara Tancredi dresses Michael's wounds, but so as not to interfere with his escape plans, Michael asks Sara not to report the incident as an intentional injury.

Lincoln and Michael take the opportunity to discuss the progress of the dig at work, and Michael decides to test his roommate Sucre's ability to keep a secret. Sucre, who misses his girlfriend Mary Cruz day and night, sees that Michael has hidden a cell phone, but under threat from prison guard Berwick, he reveals Michael's secret. But when he is threatened by guard Berrick, he reveals Michael's secret. The cell phone is only a soap-carved model, and an angry Sucre is switched to a different cell, where a mentally ill man named "Wire" becomes Michael's new roommate.

Because she was busy with the investigation, Veronica repeatedly refused her fiancé Sebastian's requests to marry her, and the two ended up breaking up. When Randica, the only lead in the murder case, is kidnapped and shot, Veronica realizes that she faces terrible resistance.

Abuzz changes tactics and takes care of Michael's "backpack" who is bent on revenge. When Abbotts asks when he will get the whereabouts of the witnesses, Michael replies, "When we break out of prison, you give me a plane and I'll give you Fibonacci."

Michael starts digging in the dead of night, but is horrified to find The Wire watching him. "The Wire calmly says that he never sleeps due to permanent nerve damage.

Episode 4

The Wire, who continues to refuse to take his medication for his mental illness, becomes so interested in Michael's tattoos that he not only follows him around, but even rips his clothes off to copy them. Meanwhile, Sucre realizes that his girlfriend, Maricruz, is falling for the lies of her suitor, Hector, and fears that by the time his 16-month sentence is up, Maricruz may have already been taken from him.

Michael gets two chemicals from the prison's storeroom and from Abbotts, and takes the opportunity of an insulin injection to pour them into the hospital's sewers, where the two agents immediately undergo a violent chemical reaction and begin to corrode the water pipes. Returning to his cell, Michael deliberately breaks his forehead and successfully drives the "wire" away, welcoming back Sucre, who is also eager to escape.

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