Discussion on Medical Gleditsia sinensis by Physicians
? According to the size of the two bars of soap, the treatment is slightly different. Tooth soap is the best for wind phlegm and big soap for wet phlegm. ? ("This Classic Meets the Original")
? Gleditsia sinensis can be treated at will. But it is enough to cure wind or wind phlegm, but it is not enough to stew with a small fire for a long time. ? (materia medica)
? Gleditsia sinensis The taste is pungent and salty, and it is good at dredging orifices and expelling wind. Therefore, when wind evil enters, it can be seen that the teeth are clenched, the mouth is silent, the chest is full of laryngitis, the abdomen is full of fetal knots, the wind is full of phlegm and wheezing, and the swelling is full of lumps, so it can be used to guide the upper and lower orifices. Decocting can treat wind phlegm and asthma. If applied, it can disperse swelling, disinfect and remove the atmosphere. If it is steamed, it will lead to constipation. Burning smoke can cure scabies and damp poison. ? ("Seeking Truth from Materia Medica")
The attached medicine Gleditsia sinensis (herbal supplement) is the thorn of Gleditsia sinensis. Leguminosae Also known as Gleditsia sinensis (Taiping Shenghui Fang), Gleditsia sinensis (Yaoyinzi) and Tianding (Compendium of Materia Medica). Pungent in taste and warm in nature. Function: searching wind and expelling toxin, reducing swelling and discharging pus. Indications: carbuncle, sore, furuncle, tinea, sore and persistent placenta. Oral administration: decoction, 3 ~10g; I still took the pills and dispersed them. External use: decoct in vinegar, grind, sprinkle or mix.
Pharmacological effects of Gleditsia sinensis;
1. Drugs containing saponins can stimulate the gastric mucosa, reflexively promote the secretion of mucus in the respiratory tract, and produce expectorant effect (nausea and expectoration). Animal experiments show that Zaojiao decoction has obvious expectorant effect and can increase the secretion of cat respiratory tract, but it is not as good as Platycodon grandiflorum and Peucedanum praeruptorum, and its duration is short.
2. Antibacterial effect In the test tube, Gleditsia sinensis has inhibitory effect on Gram-negative intestinal pathogens such as Escherichia coli, Shigella sonnei, Proteus, Typhoid Bacillus, Paratyphoid Bacillus, Pseudomonas aeruginosa and Vibrio cholerae.
Gleditsia sinensis (1:3) has inhibitory effect on dermatophytes such as Trichophyton purpurea and Nocardia stellata in vitro.
3. Other functions Gleditsia sinensis has papaverine-like effects and can treat hypertension, bronchial asthma, peptic ulcer and chronic cholecystitis.
Saponins have significant hemolysis, but the hemolysis of Gleditsia sinensis is different from the immediate hemolysis of polygala tenuifolia saponins, and generally appears later.
Gleditsia sinensis (1:230) has moderate inhibitory effect on Trichomonas vaginalis, and its mechanism is that Gleditsia sinensis saponin can make the plasma membrane of Trichomonas vaginalis thin, the cytoplasm burst and the worm body collapse.
4. General characteristics of saponins Saponins exist in hundreds of plants. It can reduce the surface tension. When the solution is shaken (1: 1000), the surface of each bubble in the solution can be surrounded by saponin to form a film, so that the foam will last. Similarly, when encountering oil, you can also form an emulsion through soap cornea. Saponins can change the permeability of cell surface and become a general protoplasm poison. It has special affinity for cholesterol and strong hemolysis (lipids act on the surface of blood cells), but its hemolysis can be resisted by cholesterol. It is very toxic to fish, and saponins are rarely absorbed by higher animals, so it mainly stimulates and secretes local mucosa.
The toxic and side effects of Gleditsia sinensis and the first-aid methods of detoxification;
Too much saponin can damage gastrointestinal mucosa or cause systemic toxicity and hemolysis by injection; In particular, it affects the central nervous system, first spasms, then paralysis, and finally dies of respiratory center paralysis.
Clinical application of this product, there have been reports of poisoning death after taking Zaojiao decoction (200g plus 1 cup of mature vinegar). A large number of saponins contained in Gleditsia sinensis not only stimulate gastrointestinal mucosa, but also vomit after 10 minutes, and then diarrhea occurs; But also corrodes gastric mucosa and causes absorption poisoning.
The poisoning symptoms of this product are: dry throat at first, hot pain, fullness in the upper abdomen and burning sensation; Then there are abdominal cramps, nausea and vomiting, irritability, diarrhea, watery stool, foamy stool, dizziness, numbness of limbs, yellow urine, pale face, jaundice and so on. Laboratory tests were consistent with acute hemolysis; Even dehydration, shock, shortness of breath, palpitation, spasm, delirium, and finally death due to respiratory paralysis.
Poisoning treatment:
1. Early gastric lavage and catharsis when necessary.
2. Rehydration as appropriate, maintain the balance of water, electrolyte and acid-base, and promote the excretion of toxins.
3. Symptomatic treatment: severe abdominal pain, intramuscular injection of atropine; Restless people are given sedatives; Patients with serious illness can receive blood transfusion and oxygen inhalation, and use hormone drugs as appropriate.