Clinical treatment of insomnia is mainly sedative and hypnotic drugs, most of which are benzodiazepines? Drugs such as estazolam and alprazolam have the functions of controlling convulsion, sedation and hypnosis, and can effectively improve the overall sleep time. However, this drug is prone to cognitive impairment, addiction and drug resistance, so its application has obvious limitations. Bailemian capsule and Shumian capsule have good substitutability.
Bailemian Capsule consists of Lily, Acanthopanax Senticosus, Polygonum Multiflori Radix, Albizia Albizziae, Concha Margarita, Gypsum Fibrosum, Semen Ziziphi Spinosae, Poria, Radix Polygalae, Radix Scrophulariae, Radix Rehmanniae, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Juncus Junci and Radix Salviae Miltiorrhizae. Has the effects of nourishing yin, clearing away heat, nourishing heart and calming nerves. It is suitable for insomnia due to liver depression and yin deficiency. The patients showed difficulty in falling asleep, dreaminess, insomnia, dizziness, fatigue, irritability and palpitation.
Among them, lily and acanthopanax senticosus are monarch drugs, which have the functions of clearing away heart fire, calming nerves, nourishing yin and clearing heat, benefiting qi and strengthening spleen. Caulis Polygoni Multiflori, Flos Albiziae, Caulis Polygoni Multiflori, Concha Margaritifera, Semen Ziziphi Spinosae, and Radix Polygalae are ministers, and Caulis Polygoni Multiflori can nourish blood, soothe nerves, dispel wind and dredge collaterals; Caulis Polygoni Multiflori can nourish the heart and soothe the nerves; Albizia Albizia can calm and hypnotize; Ziziphus jujuba seeds can nourish the liver and soothe the nerves; Polygalae helps to improve intelligence and soothe the nerves. Radix Rehmanniae, Radix Ophiopogonis, Fructus Schisandrae Chinensis, and Radix Scrophulariae are used as adjuvant drugs to nourish yin and kidney, nourish blood and replenish blood; Ophiopogon japonicus can nourish yin and promote fluid production; Schisandra chinensis can replenish qi, promote fluid production, tonify kidney and soothe the nerves; Scrophularia can clear away heat and toxic materials, relieve pain and soothe the nerves. Salvia Miltiorrhiza and Juncus Juncus can calm and hypnotize, and clear the heart fire. The combination of the above medicines can soothe the liver and relieve depression, nourish yin and clear heat, nourish blood and soothe the nerves, and calm the heart and soothe the nerves.
Modern pharmacological research shows that lilioside, the main component of lily, can play a role of sedation and hypnosis and relieve insomnia symptoms of patients. Acanthopanax senticosus contains a variety of acanthopanax senticosus glycosides and hyperoside, which can regulate the function of the central nervous system and help to improve insomnia and neurasthenia. Albizia Albizia flower can have synergistic effect with other sleeping pills. Caulis Polygoni Multiflori can prolong the slow-wave sleep time and shorten the heterogeneous sleep phase. Mother-of-pearl is mainly composed of calcium carbonate and also contains a lot of lithium, which plays an important role in regulating the central nervous system. In addition, it also contains more than 20 kinds of amino acids. Glycine can inhibit neurotransmitters and calm nerves.
Schisandra chinensis has a certain relationship with dopamine system and has a sedative effect on nervous system. Salvia miltiorrhiza can inhibit the central nervous system and improve the anxiety symptoms of patients. The ethanol extract of Juncus Juncus has obvious sedative and hypnotic effects, and the ethyl acetate part has obvious sedative effect. It can be seen that Bailemian Capsule has a synergistic effect on the treatment of anxiety insomnia through a variety of effective components, and it can produce a synergistic effect when combined with western medicine treatment, further improving the symptoms of patients.
Shumian Capsule consists of Semen Ziziphi Spinosae (parched), Radix Bupleuri (parched with wine), Radix Paeoniae Alba (parched), Flos Albizziae, Cortex Albizziae, Bombyx Batryticatus, Periostracum Cicadae and Juncus Juncus. It has the effects of soothing the liver, relieving depression, calming the heart and calming the nerves. It is suitable for insomnia with liver depression, insomnia and dreaminess, mental depression or impatience, chest pain or chest diaphragm obstruction, bitter taste and dizziness, reddish tongue tip, white or yellowish fur, and thready pulse.
Suanzaoren in the prescription tastes sour, which can calm the heart and soothe the nerves, while Bupleurum tastes bitter and cold, which can soothe the liver and relieve depression. The compatibility of the two drugs, both of which are monarch drugs, can achieve the effects of treating heart and liver together, relieving depression and calming the nerves. Albizia Albizia flower, Albizia Albizia bark and Radix Paeoniae Alba are ministerial drugs, which can calm liver yang, relieve depression and soothe the nerves, and enhance the efficacy of Ziziphus jujuba seed in nourishing blood and calming the nerves; Supplemented by cicada slough, wind-calming and spasmodic, cicada sloughing, phlegm-resolving and heat-purging, it can prevent accumulation of phlegm and drink caused by liver depression and fire, and enhance the efficacy of Chaihu in soothing the liver and relieving depression. Juncus Juncus is the medicine of this prescription. The drugs are reasonably matched, the astringency is dispersed simultaneously, and the liver and heart are given consideration, so as to achieve the effects of soothing the liver and relieving depression, calming the heart and nourishing the spirit.
Clinical research shows that Shumian capsule can quickly and effectively relieve insomnia symptoms, at the same time, it can also improve irritability and depression symptoms, shorten sleep time, improve sleep quality and improve sleep efficiency. It can regulate the contents of neurotransmitters such as serotonin and norepinephrine in the central nervous system, and effectively improve the time ratio of slow-wave sleep and fast-wave sleep. Compared with common western medicines, it has obvious advantages.
In a word, with the increase of life pressure and the change of life structure, the mental pressure of the masses has obviously increased, which has increased the incidence of insomnia to some extent. Chinese medicine has great advantages in this respect. Bailemian capsule and Shumian capsule, one is good at nourishing yin and clearing heat, nourishing heart and calming nerves, and the other is good at soothing the liver and relieving depression, calming the heart and calming nerves. Aiming at the intolerable syndrome types, it is improved from many angles, which has the characteristics of getting twice the result with half the effort and less side effects.