Coffee spot, also called milk coffee spot, is a common pigmented skin disease. About 10% to 20% of the normal population can see a single coffee spot. For most coffee spots, no special treatment is generally needed. For coffee spots on the face, neck and other parts that affect the appearance, laser treatment can be considered. However, some patients may still relapse after laser treatment. We need to pay special attention to the possibility of neurofibromatosis with multiple large coffee spots, especially six or more skin coffee spots, coffee spots with a maximum diameter above 5 mm before puberty in children, or coffee spots with a maximum diameter above 15 mm in adults. In addition, it is necessary to exclude some other manifestations of nervous system tumors and syndromes. In this case, the patient needs to find a doctor in neurosurgery and neurology to investigate.