The tetrodotoxin mainly exists in the gonads, liver, spleen, eyes, skin and blood, etc. The ovaries and liver are highly toxic, followed by the kidneys, blood, eyes, gills and skin, and the spermatheca and meat are mostly weakly toxic or non-toxic. When cooking puffer fish, the viscera and eyes of puffer fish must be strictly and carefully removed, the gills picked out, the skin peeled off, the sinews and blood removed, and the fish washed repeatedly with water. Puffer fish meat is particularly tender, flavorful and nutritious.

Every year in the spring is the spawning season of puffer fish, when the fish is the most toxic, so the spring is the high incidence of people eating puffer fish poisoning season. China's "aquatic products health management measures" clearly stipulates: "puffer fish is highly toxic, shall not enter the market. Caught toxic fish, such as puffer fish should be picked out of the box, special fixed storage", so, puffer fish or not eat for good. Only a few people are desperate to eat puffer fish, but most people do not recognize the puffer fish and accidentally eat caused by poisoning.

Pufferfish muscle can be regarded as non-toxic, so as long as you dig out the guts of the pufferfish, and then peeled off the skin, washed clean, is not toxic. However, when the pufferfish is dead for a long time, the toxins in the viscera are dissolved in the body fluids, and can penetrate into the muscles after a long time, so it is important not to be unprotected.