Vitamin B6 is essential for the metabolism of tryptophan, fat and sugar in the human body, and it is also needed for the metabolism of estrogen and corticosteroid in women. therefore, this drug is very useful for the prevention and treatment of certain women's diseases. However, if excessive intake rather bad for the body, then, what are the side effects of vitamin B6?
Side effects of vitamin B6
Long-term overdose can lead to severe peripheral neuritis, neurosensory abnormalities, gait instability, numbness in the hands and feet, and if the daily dose of 200 milligrams for more than 30 days, it has been reported to produce vitamin B6 dependence syndrome.
Precautions:
1, rare occurrence of allergic reactions;
2, and levodopa, can reduce the efficacy of levodopa;
3, cycloserine, ethylthio-isonicotinamide, chloramphenicol, hydrazine phthalazine hydrochloride, isoniazid, penicillamine, and immune suppressive agents, including glucocorticosteroids, cyclophosphamide, cyclosporine, etc. can antagonize vitamin B6 or enhance renal excretion of vitamin B6.
4, estrogen can make vitamin B6 activity in the body is reduced.
Diseases that vitamin B6 can cure:
1, general diseases:
1. atherosclerosis; 2. baldness; 3. high cholesterol; 4. cystitis; 5. facial greasiness; 6. hypoglycemia; 7. mental disorders; 8. muscular disorders; 9. neurological disorders; 10. vomiting in the early stages of pregnancy; 11. overweight; 12. post-surgery vomiting; 13 . urgency; 14. sensitivity to sunlight, etc.
2. Diabetic vascular disease
Vitamin B6 slows down vascular complications in insulin-treated diabetic rats, and vascular disease complications are a major cause of death in diabetes. Arterial disease is more prevalent in insulin-dependent (Insulin-dependent diabetes mellitus, IDDM) and non-insulin-dependent (NonInsulin-dependent diabetes mellitus, NIDDM) patients than in the general population. The vascular disease complications of diabetes mellitus are mainly due to atherosclerosis.
Endothelial injury is thought to cause atherosclerosis. Thrombogenic factors, including platelet hyperactivation (Hyperactive) or excessive platelet aggregation, contribute to the atherosclerotic process.
The activated form of vitamin B6, pyridoxal phosphate (PDP), protects vascular endothelial cells, reduces endothelial cell damage by activated platelets, inhibits platelet aggregation and blood coagulation, inhibits platelet generation of cyclic prostaglandins (Thromboxane A2, TxA2), and promotes the production of cyclic prostaglandins by vascular endothelial cells. endothelial cell production of cyclic prostaglandin (Prostaglandin I2, PGI2), as well as reducing morphological changes in vascular endothelial cells.
Damage to the vascular endothelium is recognized as an early pathology of atherosclerosis, and this alteration affects many of the functions of the vascular endothelium, including permeability, adherence, motility, and the ability of the cells to proliferate and produce material.