Hello. Fluke hepatosplenomegaly is seen in the middle and late stages of schistosomiasis. Due to the large amount of worm eggs deposited in the liver, it causes fibrosis around the portal trunk and branch system. Severe fibrosis can cause trunk and branch occlusion, and contraction can deform the liver. Due to the damage of liver cells, The main blood supply comes from small branches of the portal vein. I wish you good health

Malnutrition of the blood supply can cause atrophy and degeneration of liver cells. It is generally believed that schistosomiasis mainly causes liver fibrosis. Schistosomiasis cirrhosis often has portal hypertension. Esophageal and gastric variceal rupture and bleeding, and severe splenomegaly may occur.