The treatment principle of Henoch-Schonlein purpura therapy is to try to remove the allergenic factors. For simple patients, compound rutin, calcium, vitamin C, and antihistamine preparations can be used. For fever and arthritis, corticosteroids can be used. However, If it cannot prevent kidney invasion, inhibitors can be added to those with stubborn chronic nephritis.

Treatment methods

In the acute stage, you should stay in bed and look for allergenic factors. Suspicious foods or drugs should be temporarily avoided, or suspicious foods should be taken away from childhood under close observation. Start using it in the right amount. If there is no effect, gradually increase the amount and type of food.

TCM

Treatment based on syndrome differentiation and clinical symptoms of the disease.

Western medicine treatment

Commonly used Western medicine

1. Anti-allergic drugs: astamine, chlorpheniramine, calcium gluconate.

2. Drugs that reduce vascular permeability: Anluoxue, rutin, and vitamin C.

3. Platelet aggregation inhibitor: dipyridamole

4. Adrenocortical hormones: hydrocortisone, prednisone (prednisone), dexamethasone.

5. For patients with renal type or those who cannot be treated well with prednisone, immunosuppressive drugs (such as cyclophosphamide, azathioprine and other chemotherapy drugs) are also used.

Adrenocortical hormone treatment

Adrenocortical hormone is effective for some children and can improve symptoms. It is effective for those with abdominal pain accompanied by blood in the stool and joint symptoms, but it cannot prevent recurrence. It is often not effective for nephritis and may not be used for patients with simple skin purpura. Prednisone 1 to 2 mg/kg/day is usually taken orally in divided doses. After the symptoms are relieved, the dosage is gradually reduced until the drug is discontinued. The course of treatment is usually 1 to 2 weeks. For those with severe abdominal pain and blood in the stool or cerebral hemorrhage, hydrocortisone 150 can be used. ~300 mg/day (5-10 mg/kg/day), or dexamethasone 15-30 mg (1-2.5 mg/kg/day) for intravenous infusion. When the kidneys are affected and show nephrotic syndrome, the nephrotic syndrome

Symptomatic treatment

1. Aspirin can be used for joint swelling and pain (see the section on rheumatic fever)

2. Sedatives can be used for abdominal pain, such as Lumina, etc., and observe whether there are any signs of intussusception in the abdomen.

3. For patients with gastrointestinal bleeding, limit their diet when the amount is small, and fast when the amount is large. Procaine can also be used (should be done first). If the allergy test is negative, then use it) for vein sealing, add 8 to 15 mg/kg/day to 200 ml of 10 glucose for intravenous infusion, and 7 to 10 days is a course of treatment.

4. For those with infections, especially streptococcal infections, antibiotics such as penicillin can be used to control the infection.

5. Those with intestinal parasites must be dewormed after the gastrointestinal bleeding stops.

6. Those with lesions, such as dental caries, sinusitis, tonsillitis, etc., should be treated thoroughly.

7. Vitamin C, P or calcium can generally be supplemented.

8. Bleeding. If the amount is large and causes anemia, blood transfusion can be used.

Treatment experience

The traditional treatment of Henoch-Schonlein purpura is symptomatic treatment and the application of adrenocortical hormones, but the use of hormones will make the immune system more sensitive. Disorder, long-term use has many side effects, is easy to relapse, and is difficult to discontinue. After 1980, some people used anisodamine as the main treatment for allergic purpura, and received good results. Later, compound glycyrrhizin, etc. were added, whether it relieved symptoms or shortened the time. The course of disease and recurrence after cure are better than the use of corticosteroids. The introduction is for reference:

Basic treatment (routine treatment after admission)

Anisodamine (654-2), which has Improve microcirculation, restore autonomic movement of capillaries,

reduce exudation, regulate immunity, improve allergic inflammation, etc.

Usage: 5 glucose 250ml plus anisodamine 20~120mg1~2. Intravenous infusion once/day, the dosage is proportional to the condition of the disease (the most suitable medication is when the patient has slightly blurred vision, slightly dry mouth, etc.)

Compound glycyrrhizin has anti-allergic, anti-inflammatory, and anti-inflammatory properties. Virus regulates immunity, scavenges free radicals, etc.

Usage: 5 to 8 bottles of Linin per day for intravenous infusion of 300ml of glucose.

Symptomatic treatment

Kidney damage: Basic treatment can recover after the first onset. For patients with repeated attacks or repeated use of hormones (hormones can be reduced and stopped), the amount of basic treatment can be increased. For example, anisodamine can 2/day intravenous drip, tripterygium wilfordii can also be added.

Abdominal pain: It can be controlled by general basic treatment. In severe cases (positive fecal occult blood, bleeding, etc.), warm saline cimetidine enema can be given 1 to 2 times a day, VK1 injection, etc. Joint pain: Abnormal cardiac function, basic processing recovers quickly.

Psychiatric and nervous system: If a child appears drowsy and confused, he or she may have intracranial vasculitis or hemorrhage, which is a sign of danger. In cases of death if rescue fails, dehydration treatment should be coordinated in a timely manner.

It can also be treated with a combination of traditional Chinese and Western medicine according to the patient's condition. Western medicine is used to stabilize the acute symptoms and Chinese medicine is used for conditioning. The general treatment time is about half a year, during which the focus should be on preventing recurrence.

Physical therapy

Many patients with allergic purpura will have obvious erythema, petechiae and other skin lesions on the skin. During treatment, if you simply use drugs, it will require more time. It takes a long time to get better treatment results. If physical methods can be used to speed up the resolution of the patient's skin symptoms, it is a good auxiliary treatment method. It should be noted that some patients' constitutions are not suitable for physical treatment, so patients should ask their attending doctor when making a choice, and then proceed to treatment after confirmation.

TCM fumigation therapy:

TCM fumigation therapy uses temperature, machinery and drugs to exert therapeutic effects on the body. Warm heat stimulation causes blood vessels to dilate in the skin and affected areas, promotes local and systemic blood circulation and lymphatic circulation, increases metabolism, improves local tissue nutrition and systemic functions, unblocks meridians to coordinate qi and blood, and promotes the regulation of meridians. Through drug compatibility, some drugs can be absorbed into the body through the skin, while other drugs adhere to the skin and play a role. At the same time, they can stimulate the nerve ending receptors of the skin and form new reflexes through the nervous system, thus destroying the original ones. Pathological reflex connection to achieve the purpose of curing the disease.