1 .α- globulin production disorder anemia: anemia at birth, accompanied by jaundice, hepatosplenomegaly; 2. Homozygous (β0) globulin production disorder anemia: 1) was normal at birth, and anemia appeared several months later, showing progressive aggravation. 2) There may be fever, anorexia, diarrhea, jaundice and gradual enlargement of the liver and spleen. 3) At the age of 3 ~ 4, it is characterized by slow growth and listlessness. 3. Heterozygous (β+) globin production disorder.