The pharmacological effects of drugs for promoting blood circulation and removing blood stasis can be summarized as follows:
Drugs for promoting blood circulation and removing blood stasis generally have the functions of dilating peripheral blood vessels and increasing blood flow function of organs. 22 kinds of drugs for promoting blood circulation and removing blood stasis have effects on femoral artery blood flow and vascular resistance. It can increase femoral artery blood flow and reduce vascular resistance to varying degrees. Drugs for blood stasis generally have vasodilation effect, such as pangolin, leech, zedoary, motherwort and peach kernel, which have the dilating effect on femoral artery. Besides these, there are drugs for removing blood stasis and resolving hard mass, drugs for activating blood stasis and dilating femoral artery, and drugs for removing blood stasis and resolving hard mass have the strongest efficacy. However, this study also shows that Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, etc. have a more prominent role in dilating coronary arteries.
Angina pectoris and acute myocardial infarction of coronary heart disease have typical symptoms of blood stasis, and drugs for promoting blood circulation and removing blood stasis have good curative effect in the treatment of coronary heart disease. Many cases can prove that drugs for promoting blood circulation and removing blood stasis can increase coronary blood flow and improve oxygen supply function of myocardium, such as Salvia miltiorrhiza, Maodongqing, Carthamus tinctorius, Leonurus japonicus, Angelica sinensis, Paeonia lactiflora and Corydalis yanhusuo. Compound Danshen, Paeonia Rubra, Carthamus tinctorius, etc. From Spatholobus Spatholobus, Spatholobus Salviae Miltiorrhizae, Radix Curcumae, Olibanum, Myrrha, Sanguis Draxonis, Pollen Typhae and Tongmailing, there are similar or greater influences.
Chronic hepatitis and liver cirrhosis often have blood stasis, such as liver pain, dark skin, abdominal swelling, etc. The high-frequency impedance diagram of liver region shows that the pulsatile blood flow in liver region of patients with blood stasis is often lower than that of healthy people, and the outflow resistance is higher than that of healthy people. After promoting blood circulation and removing blood stasis, with the improvement of liver function, the pulsating blood flow in liver area increased and the outflow resistance decreased. The decrease of blood flow and cerebral blood flow, the improvement of blood circulation stasis and the improvement of cerebral circulation in patients with cerebrovascular disease. In addition, compared with patients with occlusive thromboangiitis and chronic obstructive pulmonary disease, after blood stasis, blood circulation and blood stasis, the blood flow in the diseased organs can also be increased.
Promoting blood circulation and removing blood stasis is one of the commonly used methods to treat acute abdomen with combination of traditional Chinese and western medicine. It has obvious influence on the early stage of inflammation and different types of inflammatory infiltration. From the therapeutic effect of drugs for promoting blood circulation and removing blood stasis on experimental inflammation, it can be seen that its anti-inflammatory mechanism may be due to reducing the permeability of capillaries in inflammatory areas and reducing inflammatory exudation; At the same time, the blood circulation of local tissues is improved, and the inflammatory exudate caused by absorption is promoted. In addition, some drugs for promoting blood circulation and removing blood stasis also have certain antibacterial and anti-infection effects, such as Salvia miltiorrhiza and Paeonia Rubra, which can inhibit the growth of Staphylococcus aureus, while drugs such as Paeonia Rubra and Chuanxiong can inhibit the growth of intestinal pathogenic bacteria.