The most dangerous snake venom contains neurotoxins and hemolytic enzyme toxins, such as plasmin. The protein content of the most dangerous snake crude toxin measured by Bradfordf method is 38.60%, and its LD50 value to mice is 4.3mg/kg. In addition, after intraperitoneal injection, mice immediately developed chills and systemic tremors; No food, shortness of breath, inability to open eyes, weakness of limbs, difficulty in crawling, paralysis of the whole body, loss of luster due to excessive sweating, severe convulsions, urinary incontinence and other symptoms. All the mice in the high dose group died. After dissecting the dead mice, it was found that there was a lot of congestion in the liver and spleen.
The most dangerous snake toxin is TTX-R sodium channel blocker, but it has no obvious effect on TTX-S sodium channel. Contains HVA and LVA type calcium channel ions as inhibitors.