It is mentioned in the long-term infusion will hurt the gastric mucosa as well as its own is containing certain toxins, long-term use will even lead to cancer. It is not advisable to drink more. Think about it, since there are certain toxins, and the liver's main function is to detoxify the main functions are: detoxification, metabolism, and blood clotting. So it will definitely hurt the liver more or less. But it's okay to drink it occasionally, it's good for constipated people. Here's what you need to know about Senna. Or you can go directly to the pharmacy to consult a pharmacist. Many of the people who answer questions on the Internet are not professionals, and medicine is a very rigorous subject that involves life and healing. So it is best to consult a medical professional on the spot. Pharmacological effects 1.laxative effect of this product on mice, rats, rabbits and other animals and people have a significant laxative effect, mice and rabbits in the 2-4b diarrhea after the drug, people orally about 6h caused by diarrhea. The diarrhea-causing active ingredients are mainly senna glucoside A and B, especially senna glucoside A, senna glucoside C, although the diarrhea-causing effect is similar to A, but the content is very small. Sennoside A20mg/kg can cause diarrhea in mice. But if mixed with 20% of C in A, it can make senna glucoside A effect enhancement 1.6 times. Senna glucoside in the small intestine can be partially absorbed, after the bloodstream or bile into the large intestine, and the main from the small intestine directly into the large intestine, under the action of intestinal bacteria by hydrolysis, reduction and other changes into anthrone rhubarbic acid or anthrone rhubarbic acid - 8 - glucoside. Since the laxative effect of anthrone rhubarbate injected directly is not affected, and the production of anthrone rhubarbate in the intestine is seen to be significantly reduced, it is believed that anthrone rhubarbate is the real component of senna glycosides that cause laxative effect. On the other hand, in the flip small intestine and colon sac senna glucoside can prevent glucose and Na transfer across the intestinal wall, indicating that inhibit the intestinal absorption of glucose, sodium and water, increase the intestinal lumen content of the volume of the intestinal lumen and then stimulate the intestinal wall reflexively make the small intestine and colon peristalsis enhancement may also be one of the diarrhea mechanism, and the small intestine is also the site of action of the diarrhea component. 2. hemostatic effect of gastric and duodenal hemorrhage effective. With the product of water immersion in gastroscopy sprayed on the gastric hemorrhage, visualization of the immediate hemostatic effect. Senna total glucoside 200mg/kg intraperitoneal injection can significantly shorten the bleeding time in mice. Senna oral, can be fecal platelet count and fibrinogen content increased, coagulation time, thrombin time, plasma re-calcium time and clot contraction time shortened. In addition, the protective effect of this product on hydrochloric acid and anti-inflammatory pain-induced gastric mucosal injury in rats is also conducive to the prevention and treatment of gastric and duodenal hemorrhage.3. Antibacterial effect of senna leaf infusion has an inhibitory effect on a variety of bacteria, such as Escherichia coli, Proteus, dysentery bacillus, Streptococcus aureus, as well as Candida albicans and some pathogenic skin fungi.4. Other effects for experimental intestinal infarction of the yin rats, senna glycosides 50mg/kg Intraperitoneal injection can make the reduced intestinal mucosal histamine content back to normal levels. In addition, it has been reported that this product has the effect of arrow poison, can block the transmission of nerve-muscle junction impulses, prevent the binding of acetylcholine and M receptors and cause muscle relaxation.5. Toxicity of senna total glucoside intraperitoneal injection in mice, the LD50 for 1.414g/kg, equivalent to the raw drug for the 36.3 g / kg. Testimonials from the "Drinking tablets of the new ginseng"; 1. "Journal of traditional Chinese medicine": In recent years, imported senna is often mixed with a variety of Senna genus (i.e., lentil genus) plant leaves, according to the literature and according to the specimen identification, there may be plants ear leaf Senna Cassiaauriculata L. small leaves, ovoid or obovate, apex obtuse rounded or slightly concave, or with spiny protruding, symmetric or asymmetric base, the surface of the yellowish grayish-green to reddish-brown, grayish-white hairy velvet, and some are very many. The adulteration amount of such leaves is sometimes as high as 60%. According to the Beijing Medical College Pharmaceutical Teaching and Research Group analyzed this leaf in 1959, the content of anthraquinone derivatives is very small. Therefore, the more this kind of leaf inclusions, the more inferior the quality of goods. Ear leaf senna produced in India, Sri Lanka, wild or cultivated. In foreign countries, there are still plants inverted ovate leaf senna C. obovataColladon leaves for senna leaves, but not yet seen in the country, the plant is distributed in Egypt, southern Arabia and India. Italy is cultivated, so commercially known as Italian senna. 2. According to the "Medicinal Botany and Pharmacognosy": narrow-leaved senna and pointed-leaved senna dry mature fruits (senna pods), the same function with the leaves. The side effect of abdominal pain after taking is less. Special attention to weight loss if you want to use it for weight loss, do not take it for a long time, it will cause damage to the gastric mucosa. Even lead to cancer.