It is also effective against drug-resistant Staphylococcus aureus. Then? Bactroban Mupirocin Ointment acts on the isoleucine tRNA synthetase and isoleucine binding site in the bacterial body, blocking amino acid synthesis, while depleting the intracellular tRNA, so that the RNA and protein synthesis of the sensitive bacteria is suspended. The affinity of this product for mammalian isoleucine tRNA synthetase is very low, so the toxicity to humans is very small. Mupirocin has strong antibacterial activity against aerobic gram-positive cocci, especially against Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyogenes associated with skin infections. It is also effective against drug-resistant Staphylococcus aureus. Gram-negative bacteria that are sensitive to this product include Haemophilus influenzae and Gonococcus. Bactrim Mupirocin Ointment for topical dermal application has minimal transdermal penetration and absorption. In a healthy human trial, no systemic absorption was measured with a one-time encapsulation of 70% to 80% of the body surface area of the skin with a 2% formulation of mupirocin ointment (approximately 3 g of the drug) for 8 hours or with intranasal application of the product. When the product was applied topically in psoriasis or eczema lesions, the major metabolites in the urine were equivalent to 0.4% to 0.6% of the dosage, whereas healthy skin was estimated to be below 0.2% to 0.3%. Transdermal absorption of mupirocin is minimal, and even if it enters the circulation, it is inactivated and rapidly excreted from the kidneys through the de-esterification of the vinegar bond between the paracrine chain and the nucleus into the form of monosporic acid, thus making mupirocin suitable for topical application only. Bactroban mupirocin ointment is suitable for skin infections caused by gram-positive cocci, topical application is generally no adverse reactions, occasional local itching or burning sensation, generally do not need to stop the drug. So Bactroban mupirocin ointment after the use of molting is an abnormal phenomenon, you should stop using the drug in time, if necessary, please go to the hospital.