Therefore, it is the main direction to reduce uric acid and treat gout to find the cause of uric acid increase and treat it symptomatically.
Below, "Ask the doctor" will analyze the reasons for high uric acid for you. I wish you an early diagnosis and early resolution.
The uric acid level in blood is the result of the balance between uric acid excretion and uric acid production.
Generally speaking, excessive uric acid production is the main reason for high uric acid. Further subdivision, according to the source of uric acid, can be divided into endogenous and exogenous two categories.
Endogenous uric acid is the product of cell metabolism in vivo. 80% uric acid in human body is mainly produced by metabolism. Exogenous uric acid comes from food and some drugs.
If the output of uric acid is normal, but the excretion of uric acid is small due to kidney problems, it can also lead to uric acid accumulation.
The skewness of uric acid products can be subdivided into endogenous and exogenous products.
Common conditions of endogenous blood uric acid production
1, tumor
Such as leukemia, lymphoma, myeloma, liver cancer and lung cancer. The rapid growth, proliferation and dissolution of tumor cells can lead to vigorous nucleic acid metabolism and excessive uric acid production.
2. Excessive cell destructive diseases
Purine is an important part of cellular genetic material. If a large number of cells die, a large number of purines will be released.
Therefore, severe burns, trauma, chemotherapy and radiotherapy of cancer patients will lead to excessive destruction of cells in the body, which will lead to excessive uric acid production in the body and hyperuricemia.
Common conditions of exogenous blood uric acid production
1, food factor
Long-term intake of foods with high purine content will also lead to an increase in uric acid in the body, leading to abnormal uric acid concentration.
This is the main factor of high uric acid in China at present.
Common foods with high purine content are seafood > meat > fruits and vegetables.
In addition, oil consumption, abalone sauce, shrimp sauce and other seasonings have high purine content.
2. Drug factors
Taking some drugs can inhibit uric acid excretion, lead to uric acid deposition and increase uric acid level. Such drugs include:
In addition to the above two types of increased uric acid production, uric acid excretion is blocked, which will also lead to excessive accumulation of uric acid in the body.
(1) Abnormal renal function
Kidney has the function of excreting metabolites, and uric acid is one of them. After the renal function is abnormal, the ability of the kidney to excrete metabolites is obviously reduced, resulting in excessive uric acid not being excreted, which leads to the increase of uric acid.
(2) acidosis
If acidosis exists, it will also lead to uric acid excretion disorder. When the concentration of lactic acid or ketoacid increases, the excretion of uric acid by renal tubules is competitively inhibited, and the excretion decreases, which may lead to hyperuricemia.
(3) Excessive drinking
Alcohol excretion will also competitively crowd out uric acid excretion channels. It will aggravate the problem of high uric acid.
If uric acid is too high in blood is deposited in many organs and tissues, it will cause diseases:
(1) deposited on the joint.
Long-term urate crystal deposition on joints will cause joint swelling, fever, pain and other diseases, and become gout. In addition to abnormal joint pain, high uric acid can also lead to bone destruction and bone loss.
(2) Intrarenal deposition
Gouty nephropathy, 10%-40% patients will have kidney calculi for the first time, and severe cases may have renal insufficiency or even failure.
(3) deposited in the urinary tract
Causing urinary calculi, causing discomfort such as low back pain, frequent urination, urgency and dysuria.
(4) aggravating cardiovascular diseases
Studies have shown that the incidence of acute myocardial infarction in gout patients is 26% higher than that in normal people, and the death risk of coronary heart disease caused by hyperuricemia can even increase by more than 50%.
(5) Aggravate metabolic diseases such as diabetes.
20%~50% patients with hyperuricemia have diabetes.
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