The reason why piperine can be dissolved in acid water is that a chemical reaction occurs between the two.

The reactive site of piperine, that is, the double bond site, is prone to addition reactions, the amide bond is prone to alkaline hydrolysis, and the ether bond of the oxygen heterocycle is prone to acid hydrolysis to open the ring, and the two will undergo chemical reactions.

Piperine is a broad-spectrum anticonvulsant.