Contents 1 Pinyin 2 English reference 3 Overview 4 Latin name 5 English name 6 Nicknames for Zi Wei Zi 7 Prescription names for Zi Wei Zi 8 Source 9 Origin 10 Harvesting and primary processing 11 Zi Wei Zi’s Preparation 11.1 Processing method of 茺伟子11.1.1 茺伟子11.1.2 Stir-fried 茺伟子11.2 Properties of the finished product 11.3 Quality requirements 11.4 Processing effect 11.5 Storage method 12 Meridian tropism of nature and flavor 13 Efficacy and indications of 茺伟子14 Contraindications for use 15 Usage and dosage of Mongweizi 16 Chemical composition of Mongweizi 17 Pharmacological effects of Mongweizi 18 Poisoning of Mongweizi 18.1 Adverse reaction mechanism 18.2 Symptoms of Mongweizi 18.3 Treatment 19 Pharmacopoeia standards of Mongweizi 19.1 Product name 19.2 Source 19.3 Characteristics 19.4 Identification 19.5 Inspection 19.5.1 Moisture content 19.5.2 Total ash content 19.6 Leachate 19.7 Content determination 19.7.1 Chromatographic conditions and system suitability 19.7.2 Preparation of reference solution 19.7.3 Preparation of test solution 19.7.4 Determination method 19.8 Ganweizi decoction pieces 19.8.1 Preparation 19.8.1.1 Stir-fried Ganweizi 19.8.2 Nature, flavor and meridians 19.8.3 Function and indications 19.8.4 Usage and dosage 19.8.5 Notes 19.8.6 Storage 19.9 Source 20 References attached : 1 Prescriptions using the traditional Chinese medicine Fructus Fructus 2 Chinese patent medicines using the Chinese medicine Fructus 3 Fructus in ancient books 1 Pinyin
chōng wèi zǐ 2 English reference
fructus leonuri [Landau Chinese-English Dictionary]
leonuri fructus [Xiangya Medical Professional Dictionary]
motherwort fruit [Xiangya Medical Professional Dictionary]
wormwoodlike motherwort fruit [Xiangya Medical Professional Dictionary]
LEONURI FRUCTUS ["Chinese People's Republic of China Pharmacopoeia" 2010 Edition]
Fructus Leonuri (La) [ Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)]
motherwort fruit [Traditional Chinese Medicine Terminology Approval Committee. Traditional Chinese Medicine Terminology (2004)] 3 Overview
Motherwort fruit is a traditional Chinese medicine Famous, published in "Shen Nong's Materia Medica". It is the dried and mature fruit of the Lamiaceae plant Leonurus japonicus Houtt.[1].
The taste of Ziwei Zi is pungent, bitter, and slightly cold in nature [1]. Returns to the pericardium and liver meridians[1]. It has the functions of promoting blood circulation, regulating menstruation, clearing the liver and improving eyesight [1]. It is used for irregular menstruation, amenorrhea, dysmenorrhea, red eyes, dizziness, swelling and pain. The raw product of Ziweizi is good at clearing the liver and improving eyesight, and is mostly used for red, swollen and painful eyes or filmy eyes [1]. Stir-fried Ganwei Zi is cold in nature and brittle, and is easy to decoct to extract the active ingredients. It is good at activating blood circulation and regulating menstruation. It can be used for irregular menstruation, dysmenorrhea, and postpartum blood stasis and abdominal pain [1].
"The Pharmacopoeia of the People's Republic of China" (2010 edition) records the pharmacopoeia standards of this traditional Chinese medicine.
4 Latin name
Fructus Leonuri (La) ("Terms of Traditional Chinese Medicine (2004)") 5 English name
motherwort fruit ("Terms of Traditional Chinese Medicine (2004)") 6 Wei Alias ??of seeds
Emperoria japonicus, Kuncaozi, Motherwort, wild jute, Hexagonal gastrodia, oxenia, chisel, Yuxiacao, Prunella vulgaris, Triangle, Chongyuzi, Vallisneria, small flax [2].
Motherwort seeds and flaxseed[3]. 7. Prescription names for Cortex Cortex
Cortex Cortex, Motherwort Seed, Fried Cortex Cortex [1]. 8 Sources
It is the dried and mature fruit of the Lamiaceae plant Leonurus japonicus Houtt.[1].
Leonurusheterophyllus Sweet is the fruit of the Lamiaceae plant Leonurusheterophyllus Sweet[3].
Nigeria is the mature fruit of the Lamiaceae plant Motherwort or Motherwort [2]. 9 Origin
It is produced in most parts of the country [3]. 10 Harvesting and initial processing
When the fruits mature in autumn, harvest the above-ground parts, dry them in the sun, break the fruits, and remove impurities [1]. 11 The preparation of Ji Weizi
In the Song Dynasty, there was fried brown ("Chanyu Baoqing Collection") [1].
In the Ming Dynasty, there was a saying that "slightly stir-fry until fragrant, or steam, dry in the hot sun, pound and winnow, remove the shells, and use the kernels" ("Compendium of Materia Medica") [1].
In the Qing Dynasty, there was a saying: "Slightly stir-fry until fragrant, steam until fragrant, dry in the hot sun, remove the shells with a pestle and mix with Tongjiang old wine, steam for nine times and dry for nine times" ("Ben Jing Feng Yuan"); wash thoroughly with wine ("Compendium of Materia Medica") )[1].
The main cooking methods now include stir-frying [1]. 11.1 Preparation method of Zi Wei Zi 11.1.1 Zi Wei Zi
Take the raw medicinal materials, remove impurities, wash and dry [1]. Mash it when used [1]. 11.1.2 Stir-fried Ganwei Zi
Take the clean Ganwei Zi, place it in a frying container, heat it over a slow fire, stir-fry until there is a crackling sound, the surface color deepens, and the cross section is light yellow, take it out [1] . Mash it when used [1]. 11.2 Characteristics of the finished product
The fruit is triangular in shape, with a gray-brown to gray-brown surface with dark spots. One end is slightly wider and truncated, and the other end is narrower and blunter [1]. The peel is thin, the cotyledons are white, and rich in oil [1]. Odorless and bitter [1].
The surface of the stir-fried fenugreek seeds is slightly bulging and the color is deepened[1]. 11.3 Quality requirements
The total ash content of Xiweizi shall not exceed 10.0%[1]. 11.4 Preparation effect
The raw product of Ziweizi is good at clearing the liver and improving eyesight, and is mostly used for red, swollen and painful eyes or filmy eyes [1].
The cold nature of stir-fried Ganwei Zi is weakened and the texture is brittle. It is easy to fry out the active ingredients and is good at promoting blood circulation and regulating menstruation [1]. It can be used for irregular menstruation, dysmenorrhea, and postpartum blood stasis and abdominal pain [1].
Experiments have shown that the total water-soluble components of Ziwei Zi are higher in all processed products than in raw products [1]. Among them, the slightly fried products and the wine-fried products have very significant differences compared with the raw products. For general diseases, lightly fried products are better, and for head diseases, wine-fried ones are better [1]. 11.5 Storage method
Store in a dry container, sealed, in a ventilated and dry place [1]. Mothproof[1]. 12. Meridian distribution of nature and flavor
The taste of Ziweizi is pungent, bitter, and slightly cold in nature; it returns to the pericardium and liver meridians. ("Chinese People's Pharmacopoeia" (2010 edition))
The taste of Zi Weizi is pungent, bitter, and slightly cold in nature; it returns to the pericardium and liver meridians [1].
Ziwei Zi tastes pungent, sweet, slightly cold in nature, and is slightly toxic; it enters the liver and spleen meridians [3]. 13 Efficacy and Indications of Zi Wei Zi
Zi Wei Zi has the functions of promoting blood circulation, regulating menstruation, clearing the liver and improving eyesight [1]. It is used for irregular menstruation, amenorrhea, dysmenorrhea, red eyes, dizziness and pain (2010 edition of Chinese Pharmacopoeia).
The raw product of Ziweizi is good at clearing the liver and improving eyesight, and is mostly used for red, swollen and painful eyes or filmy eyes[1].
The cold nature of stir-fried Ganwei Zi is weakened and the texture is brittle. It is easy to fry out the active ingredients and is good at promoting blood circulation and regulating menstruation [1]. It can be used for irregular menstruation, dysmenorrhea, and postpartum blood stasis and abdominal pain [1].
Ziweizi has the effects of promoting blood circulation and regulating menstruation, clearing the liver and improving eyesight. It can treat irregular menstruation, menstruation, vaginal discharge, postpartum blood stasis and abdominal pain, hypertension, red eyes, swelling and pain [3].
Ganweizi is a medicine commonly used in ophthalmology to promote blood circulation and remove blood stasis. It has the effects of promoting blood circulation and removing blood stasis, cooling the liver and improving eyesight:
(1) It is used for intraocular bleeding, long-lasting blood stasis, and blood stasis. Dark eyes or tight pupils, etc. This product is used to achieve the effect of removing blood stasis and regenerating blood. It is often combined with Chuanxiong, peach kernel, safflower, etc.
(2) It is used for the symptoms of shyness, tearing, red and swollen eyes, or dark eyes caused by excess heat in the liver meridian. It can be used in combination with Cassia, Cassia Seed, Qinghuizi, etc.
(3) It is used for dizziness caused by liver and kidney yin deficiency. It is often used in combination with wolfberry, dodder, etc. 14 Contraindications for use
Zi Weizi has the effect of dilating pupils, so patients with cyanotic cataracts and cyanotic cataracts should use it with caution. 15 Usage and dosage of Ziweizi
Decoction: 3~9g[3]. 16 The chemical composition of wolfberry seeds
Chrysanthemum seeds contain oleic acid, linoleic acid, linolenic acid, and palmitic acid; biological agents, such as motherwort and stachin; flavonoids and their glucosides[1] .
Nanweizi contains motherwort and vitamin A substances [3]. 17 Pharmacological effects of Zi Wei Zi
Intravenous injection of water extract of Zi Wei Zi can reduce the blood pressure of animals without uterine contraction [3]. 18. Poisoning of Zi Wei Zi
Zi Wei Zi contains motherwort. Excessive dosage will first excite and then inhibit the nervous system, eventually leading to paralysis.
Taking more than 30g of Ziweizi at one time can cause poisoning, general weakness, body aches, inability to move the lower limbs, and even sweating and collapse [3]. 18.1 Adverse reaction mechanism
This product is generally decoction and has no obvious toxicity when taken orally. The usual dosage for oral administration is 6 to 10g. Recently, it has been reported that taking 20 to 30g of 茺伟子粉 can cause poisoning. Ziweizi contains motherwort. Excessive dosage can first excite and then inhibit the nervous system, eventually leading to paralysis. It has a curare-like paralyzing effect on motor nerve endings, and has vasodilatory and uterine contraction effects. [2] 18.2 Symptoms of 茺伟子
躺伟子 poisoning manifests as sudden general weakness, numbness of the limbs, body aches, inability to move the lower limbs, paralysis, chest tightness, sweating and collapse. [2] 18.3 Treatment
The key points of treatment for poisoning by 茺伟子 are [2]:
See the related content of Motherwort:
1. Vomiting should be induced in the early stage, Gastric lavage and intravenous infusion of 5% glucose saline are performed to promote toxin excretion and maintain water and electrolyte balance.
2. Symptomatic treatment: When blood pressure drops, vasopressors should be used with caution, and intravenous infusion of norepinephrine can be used to keep blood pressure close to normal levels. If there is bleeding, hemostatic drugs can be given, and blood transfusions can be given if necessary. If there is difficulty breathing, oxygen and respiratory stimulants can be given. 19 Pharmacopoeia standard of Chongweizi 19.1 Product name
Chongweizi
Chongweizi
LEONURI FRUCTUS 19.2 Source
This product is lip-shaped The dried and ripe fruits of Leonurus japonicus Houtt. In autumn, when the fruits are mature, the above-ground parts are harvested, dried in the sun, and the fruits are cut to remove impurities. 19.3 Properties
This product is triangular in shape, 2 to 3mm long and about 1.5mm wide. The surface is gray-brown to gray-brown with dark spots. One end is slightly wider and truncate-shaped, and the other end becomes narrower and blunter. The peel is thin, the cotyledons are white, and rich in oil. The smell is slight and the taste is bitter. 19.4 Identification
(1) The powder of this product is yellow-brown to dark brown. The cross-sectional view of the epicarp cells is slightly elongated in a radial direction, with varying lengths, forming many raised ridges. In the center of the ridges are yellow reticulated cells, with non-lignified walls; the surface is polygonal, with striped horny textures, and the reticulated cells have Strip-shaped thickened walls.
The endocarp thick-walled cells are slightly tangentially elongated in cross-section, with extremely thick inner walls and thin outer walls. The cell cavity is toward the outside and contains cubic crystals of calcium oxalate; the surface view is star-shaped or the cell boundaries are not obvious and the cubic crystals are obvious. The surface of the mesocarp cells is polygonal in appearance, with thin walls and fine wavy curves. The epidermal cells of the seed coat are square in shape, with slightly thicker walls and slightly wavy curves, and the cell cavity contains light yellowish-brown material. The endosperm cells contain fatty oil droplets and aleurone grains.
(2) Take 3g of this product powder, add 30ml of ethanol, heat and reflux for 1 hour, let it cool, filter, concentrate the filtrate to about 5ml, add it to an activated carbon alumina column (0.5g of activated carbon; medium (100~120 mesh, 2g; inner diameter: 10mm), elute with 30ml of ethanol, collect the eluate, evaporate to dryness, add 0.5ml of ethanol to the residue to dissolve, and use it as the test solution. Take another stachohydrochloride reference substance, add ethanol to make a solution containing 5 mg per 1ml, and use it as the reference solution. According to the thin layer chromatography (Appendix VI B of Pharmacopoeia 2010 edition) test, take 10 μl of each of the above two solutions and spot them on the same silica gel G thin layer plate. Use n-butanol hydrochloric acid water (4:1:0.5) as the test method. Develop the developing agent, take it out, dry it, and spray it with dilute bismuth potassium iodide test solution. In the chromatogram of the test product, spots of the same color appear at the positions corresponding to the chromatogram of the reference substance. 19.5 Inspection 19.5.1 Moisture content
shall not exceed 7.0% (Appendix IX H of the 2010 edition of the Pharmacopoeia, Method 1). 19.5.2 Total ash content
shall not exceed 10.0% (2010 edition of Pharmacopoeia, Appendix IX K). 19.6 Leachables
Determine according to the hot soak method under the determination method of alcohol-soluble leachables (Appendix 19.7 Content determination
Determine according to high performance liquid chromatography (2010 edition of Pharmacopoeia, Appendix VI D). 19.7.1 Chromatographic conditions and system suitability
Test strong cation exchange (SCX) chromatographic column; use 15mmol/L potassium dihydrogen phosphate solution (containing 0.06% triethylamine and 0.14% phosphoric acid) as the mobile phase ;The detection wavelength is 192nm. The number of theoretical plates should not be less than 3,000 based on the peak value of stachylohydrochloride. 19.7.2 Preparation of reference substance solution
Take an appropriate amount of stachodin hydrochloride reference substance, weigh it accurately, add mobile phase to make a solution containing 40ug per 1ml, and you have it. 19.7.3 Preparation of test solution
Take about 1g of this product powder (passed through No. 3 sieve), weigh it accurately, place it in a stoppered conical flask, add 25ml of ethanol accurately, and seal tightly. Determine the weight, heat and reflux for 1.5 hours, let cool, weigh again, make up for the lost weight with ethanol, shake well, filter, accurately measure 5 ml of the additional filtrate, and add it to a neutral alumina column (100-200 mesh) , 3g, inner diameter 1cm, wet packing column, pre-washed with ethanol), elute with 100ml ethanol, collect the eluent, recover the solvent to dryness, add mobile phase to dissolve the residue, transfer to a 5ml measuring bottle, and dilute Reach the mark, shake well, filter, and take the remaining filtrate to get it. 19.7.4 Determination method
Precisely draw 10ul each of the reference solution and the test solution, inject them into the liquid chromatograph, and measure.
Calculated as a dry product, this product contains not less than 0.050% stachenyl hydrochloride (C7H13NO2?HC1). [4] 19.8 Miaoweizi decoction pieces 19.8.1 Preparation 19.8.1.1 Stir-fried Miaoweizi
Take the clean Miaoweizi and fry according to the clear frying method (Appendix II D of the 2010 edition of the Pharmacopoeia) until it explodes Voice. 19.8.2 Nature, flavor and meridians
Pungent, bitter and slightly cold. Returns to pericardium and liver meridian. 19.8.3 Functions and indications
Promotes blood circulation, regulates menstruation, clears liver and improves eyesight. It is used for irregular menstruation, amenorrhea, dysmenorrhea, red eyes, dizziness, swelling and pain. 19.8.4 Usage and dosage
5～10g. 19.8.5 Note
People with dilated pupils should use with caution. 19.8.6 Storage
Store in a ventilated and dry place. 19.9 Source