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Is autoimmune disease a genetic disease?
Not necessarily. Autoimmune diseases caused by genetic material changes caused by inbreeding and embryo development are likely to be passed on to future generations, while acquired autoimmune diseases are generally not passed on to future generations. Autoimmune diseases refer to diseases in which the body has an immune response to its own antigens, resulting in damage to its own tissues. Many diseases have been classified as autoimmune diseases. It is worth mentioning that the existence of autoantibodies and autoimmune diseases are not two equivalent concepts. Autoantibodies can exist in normal people without autoimmune diseases, especially in the elderly, such as anti-thyroglobulin antibodies, thyroid epithelial cell antibodies, gastric parietal cell antibodies, nuclear DNA antibodies and so on. Sometimes, damaged or antigenically altered tissues will stimulate the production of autoantibodies. For example, when myocardial ischemia occurs, necrotic myocardium can lead to the formation of anti-myocardial autoantibodies, but this antibody has no pathogenic effect and is a secondary immune response.