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Do uric acid-lowering drugs affect the treatment of heart failure?
Patients with heart failure whose serum uric acid is >: 480 μmol/L or who have a history of gouty arthritis need medication to reduce uric acid, and long-term management can keep the serum uric acid below the target value. The prevalence of hyperuricemia in patients with chronic heart failure is as high as 50%. Allopurinol is recommended as the first choice for reducing uric acid in patients with heart failure without contraindications. At present, there is no evidence that uric acid therapy has beneficial effects on left ventricular function, symptoms or prognosis in patients with heart failure. Cardiac resynchronization therapy (CRT) is a more effective treatment for patients who are ineffective in drug therapy or whose hearts are out of sync. CRT realizes the optimal sequential activation of atrium and ventricle through biventricular pacing, thus increasing diastolic filling time, helping the left and right ventricles of the heart to contract synchronously, reducing mitral regurgitation, and increasing stroke output through inter-ventricular and indoor resynchronization contraction. Effectively help the heart to provide enough power to pump blood to the whole body, increase cardiac output, improve heart function, and gradually restore the heart to normal size, thus realizing the treatment of heart failure. CRT is an effective instrument therapy for heart failure at present, and there is no evidence that uric acid lowering drugs have a clear effect on the therapeutic effect of CRT.